Doxorubicin triggers bioenergetic failure and p53 activation in mouse stem cell-derived cardiomyocytes.

Cunha-Oliveira, Teresa; Ferreira, Luciana L; Coelho, Ana Raquel; Deus, Cláudia M; Oliveira, Paulo J

Cunha-Oliveira, Teresa; Ferreira, Luciana L; Coelho, Ana Raquel; Deus, Cláudia M; Oliveira, Paulo J.

Affiliation

Cunha-Oliveira T; CNC, Center for Neuroscience and Cell Biology, University of Coimbra, UC-Biotech Building, Biocant Park, Cantanhede, Portugal. Electronic address: teresa.oliveira@uc-biotech.pt.
Ferreira LL; CNC, Center for Neuroscience and Cell Biology, University of Coimbra, UC-Biotech Building, Biocant Park, Cantanhede, Portugal.
Coelho AR; CNC, Center for Neuroscience and Cell Biology, University of Coimbra, UC-Biotech Building, Biocant Park, Cantanhede, Portugal; Institute for Interdisciplinary Research (I.I.I.), University of Coimbra, 3030-789 Coimbra, Portugal.
Deus CM; CNC, Center for Neuroscience and Cell Biology, University of Coimbra, UC-Biotech Building, Biocant Park, Cantanhede, Portugal; Institute for Interdisciplinary Research (I.I.I.), University of Coimbra, 3030-789 Coimbra, Portugal.
Oliveira PJ; CNC, Center for Neuroscience and Cell Biology, University of Coimbra, UC-Biotech Building, Biocant Park, Cantanhede, Portugal; Institute for Interdisciplinary Research (I.I.I.), University of Coimbra, 3030-789 Coimbra, Portugal.

Toxicol Appl Pharmacol ; 348: 1-13, 2018 06 01.

Article in En | MEDLINE | ID: mdl-29653124

Subject(s)

Antibiotics, Antineoplastic/toxicity; Doxorubicin/toxicity; Energy Metabolism/drug effects; Heart Diseases/chemically induced; Induced Pluripotent Stem Cells/drug effects; Myocytes, Cardiac/drug effects; Tumor Suppressor Protein p53/metabolism; Adenosine Triphosphate/metabolism; Animals; Apoptosis/drug effects; Cardiotoxicity; Cell Differentiation; Cell Line; DNA Damage; Dose-Response Relationship, Drug; Heart Diseases/genetics; Heart Diseases/metabolism; Heart Diseases/pathology; Induced Pluripotent Stem Cells/metabolism; Induced Pluripotent Stem Cells/pathology; Mice; Mitochondria, Heart/drug effects; Mitochondria, Heart/metabolism; Mitochondria, Heart/pathology; Myocytes, Cardiac/metabolism; Myocytes, Cardiac/pathology; Poly (ADP-Ribose) Polymerase-1/metabolism; Protein Serine-Threonine Kinases/genetics; Protein Serine-Threonine Kinases/metabolism; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Pyruvate Dehydrogenase Complex/metabolism; Superoxide Dismutase/metabolism; Tumor Suppressor Protein p53/genetics

Key words

Apoptosis; Cancer chemotherapy; Cardiotoxicity; Doxorubicin; Mitochondria; Pyruvate Dehydrogenase (PDH)

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Full text: 1 Database: MEDLINE Therapeutic Methods and Therapies TCIM: Terapias_energeticas / Bioenergetica Main subject: Doxorubicin / Tumor Suppressor Protein p53 / Myocytes, Cardiac / Energy Metabolism / Induced Pluripotent Stem Cells / Heart Diseases / Antibiotics, Antineoplastic Language: En Journal: Toxicol Appl Pharmacol Year: 2018 Type: Article

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