Effect of hemin, baicalein and heme oxygenase-1 (HO-1) enzyme activity inhibitors on Cd-induced accumulation of HO-1, HSPs and aggresome-like structures in Xenopus kidney epithelial cells.

Campbell, James H; Heikkila, John J

Campbell, James H; Heikkila, John J.

Affiliation

Campbell JH; Department of Biology, University of Waterloo, Waterloo, ON N2L 3G1, Canada.
Heikkila JJ; Department of Biology, University of Waterloo, Waterloo, ON N2L 3G1, Canada. Electronic address: heikkila@uwaterloo.ca.

Comp Biochem Physiol C Toxicol Pharmacol ; 210: 1-17, 2018 Aug.

Article in En | MEDLINE | ID: mdl-29698685

Subject(s)

Cadmium/toxicity; Environmental Pollutants/toxicity; HSP30 Heat-Shock Proteins/metabolism; HSP70 Heat-Shock Proteins/metabolism; Heme Oxygenase-1/metabolism; Kidney/drug effects; Protein Aggregation, Pathological/chemically induced; Animals; Antioxidants/chemistry; Antioxidants/metabolism; Cell Line; Dietary Supplements; Enzyme Inhibitors/pharmacology; Flavanones/antagonists & inhibitors; Flavanones/metabolism; Heme Oxygenase-1/antagonists & inhibitors; Heme Oxygenase-1/chemistry; Hemin/antagonists & inhibitors; Hemin/metabolism; Intrinsically Disordered Proteins/chemistry; Intrinsically Disordered Proteins/metabolism; Kidney/cytology; Kidney/metabolism; Kidney/pathology; Metalloporphyrins/pharmacology; Microscopy, Confocal; Protein Aggregation, Pathological/pathology; Protein Aggregation, Pathological/prevention & control; Protoporphyrins/pharmacology; Xenopus Proteins/agonists; Xenopus Proteins/antagonists & inhibitors; Xenopus Proteins/chemistry; Xenopus Proteins/metabolism; Xenopus laevis

Key words

Aggregated protein; Aggresomes; Cadmium; Cytoskeleton; HO-1; HSP30; HSP70; Immunocytochemistry; SnPP; ZnPP

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Full text: 1 Database: MEDLINE Main subject: Cadmium / HSP70 Heat-Shock Proteins / Environmental Pollutants / Heme Oxygenase-1 / HSP30 Heat-Shock Proteins / Protein Aggregation, Pathological / Kidney Language: En Journal: Comp Biochem Physiol C Toxicol Pharmacol Year: 2018 Type: Article Affiliation country: Canada

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