Permeability of glibenclamide through a PAMPA membrane: The effect of co-amorphization.

Ruponen, Marika; Visti, Maiju; Ojarinta, Rami; Laitinen, Riikka

Ruponen, Marika; Visti, Maiju; Ojarinta, Rami; Laitinen, Riikka.

Affiliation

Ruponen M; School of Pharmacy, University of Eastern Finland, P.O. Box 1627, 70211 Kuopio, Finland.
Visti M; School of Pharmacy, University of Eastern Finland, P.O. Box 1627, 70211 Kuopio, Finland.
Ojarinta R; School of Pharmacy, University of Eastern Finland, P.O. Box 1627, 70211 Kuopio, Finland.
Laitinen R; School of Pharmacy, University of Eastern Finland, P.O. Box 1627, 70211 Kuopio, Finland. Electronic address: riikka.laitinen@uef.fi.

Eur J Pharm Biopharm ; 129: 247-256, 2018 Aug.

Article in En | MEDLINE | ID: mdl-29894814

Subject(s)

Drug Compounding/methods; Drug Evaluation, Preclinical/methods; Drug Liberation; Glyburide/pharmacokinetics; Membranes, Artificial; Arginine/chemistry; Calorimetry, Differential Scanning; Chemistry, Pharmaceutical/methods; Drug Evaluation, Preclinical/economics; Drug Stability; Feasibility Studies; Glyburide/chemistry; Permeability; Polymers/chemistry; Serine/chemistry; Sodium Dodecyl Sulfate/chemistry; Solubility; X-Ray Diffraction

Key words

Co-amorphous; Dissolution; PAMPA; Permeability; Solubility; Stability

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Full text: 1 Database: MEDLINE Main subject: Glyburide / Drug Compounding / Drug Evaluation, Preclinical / Drug Liberation / Membranes, Artificial Language: En Journal: Eur J Pharm Biopharm Year: 2018 Type: Article Affiliation country: Finland

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