Coordinated autophagy modulation overcomes glioblastoma chemoresistance through disruption of mitochondrial bioenergetics.

Kriel, Jurgen; Müller-Nedebock, Kristian; Maarman, Gerald; Mbizana, Siyasanga; Ojuka, Edward; Klumperman, Bert; Loos, Ben

Kriel, Jurgen; Müller-Nedebock, Kristian; Maarman, Gerald; Mbizana, Siyasanga; Ojuka, Edward; Klumperman, Bert; Loos, Ben.

Affiliation

Kriel J; Department of Physiological Sciences, Faculty of Science, University of Stellenbosch, Stellenbosch, 7600, South Africa.
Müller-Nedebock K; Department of Physics, Faculty of Science, University of Stellenbosch, Stellenbosch, 7600, South Africa.
Maarman G; Division of Exercise Science and Sports Medicine Institute (ESSM), Department of Human Biology, University of Cape Town, Cape Town, 7700, South Africa.
Mbizana S; Department of Polymer Science, Faculty of Science, University of Stellenbosch, Stellenbosch, 7600, South Africa.
Ojuka E; Division of Exercise Science and Sports Medicine Institute (ESSM), Department of Human Biology, University of Cape Town, Cape Town, 7700, South Africa.
Klumperman B; Department of Polymer Science, Faculty of Science, University of Stellenbosch, Stellenbosch, 7600, South Africa.
Loos B; Department of Physiological Sciences, Faculty of Science, University of Stellenbosch, Stellenbosch, 7600, South Africa. bloos@sun.ac.za.

Sci Rep ; 8(1): 10348, 2018 07 09.

Article in En | MEDLINE | ID: mdl-29985441

Subject(s)

Autophagy; Drug Resistance, Neoplasm; Mitochondria/metabolism; Antineoplastic Agents/pharmacology; Autophagy/drug effects; Autophagy-Related Protein 5/antagonists & inhibitors; Autophagy-Related Protein 5/genetics; Autophagy-Related Protein 5/metabolism; Brain Neoplasms/metabolism; Brain Neoplasms/pathology; Cell Line, Tumor; Cell Survival/drug effects; Drug Resistance, Neoplasm/drug effects; Electron Transport Complex I/metabolism; Glioblastoma/metabolism; Glioblastoma/pathology; Humans; Lactic Acid/metabolism; Mitochondrial Dynamics/drug effects; Oxidative Phosphorylation/drug effects; RNA Interference; RNA, Small Interfering/metabolism; Temozolomide/pharmacology

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Full text: 1 Database: MEDLINE Therapeutic Methods and Therapies TCIM: Terapias_energeticas / Bioenergetica Main subject: Autophagy / Drug Resistance, Neoplasm / Mitochondria Language: En Journal: Sci Rep Year: 2018 Type: Article Affiliation country: South Africa

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