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Spatially constrained tandem bromodomain inhibition bolsters sustained repression of BRD4 transcriptional activity for TNBC cell growth.
Ren, Chunyan; Zhang, Guangtao; Han, Fangbin; Fu, Shibo; Cao, Yingdi; Zhang, Fan; Zhang, Qiang; Meslamani, Jamel; Xu, Yaoyao; Ji, Donglei; Cao, Lingling; Zhou, Qian; Cheung, Ka-Lung; Sharma, Rajal; Babault, Nicolas; Yi, Zhengzi; Zhang, Weijia; Walsh, Martin J; Zeng, Lei; Zhou, Ming-Ming.
Affiliation
  • Ren C; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
  • Zhang G; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
  • Han F; Bethune Institute of Epigenetic Medicine, The First Hospital, Jilin University, 130061 Changchun, China.
  • Fu S; Bethune Institute of Epigenetic Medicine, The First Hospital, Jilin University, 130061 Changchun, China.
  • Cao Y; Bethune Institute of Epigenetic Medicine, The First Hospital, Jilin University, 130061 Changchun, China.
  • Zhang F; Bethune Institute of Epigenetic Medicine, The First Hospital, Jilin University, 130061 Changchun, China.
  • Zhang Q; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
  • Meslamani J; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
  • Xu Y; Bethune Institute of Epigenetic Medicine, The First Hospital, Jilin University, 130061 Changchun, China.
  • Ji D; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
  • Cao L; Bethune Institute of Epigenetic Medicine, The First Hospital, Jilin University, 130061 Changchun, China.
  • Zhou Q; Bethune Institute of Epigenetic Medicine, The First Hospital, Jilin University, 130061 Changchun, China.
  • Cheung KL; Bethune Institute of Epigenetic Medicine, The First Hospital, Jilin University, 130061 Changchun, China.
  • Sharma R; Bethune Institute of Epigenetic Medicine, The First Hospital, Jilin University, 130061 Changchun, China.
  • Babault N; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
  • Yi Z; Bethune Institute of Epigenetic Medicine, The First Hospital, Jilin University, 130061 Changchun, China.
  • Zhang W; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
  • Walsh MJ; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
  • Zeng L; Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
  • Zhou MM; Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Proc Natl Acad Sci U S A ; 115(31): 7949-7954, 2018 07 31.
Article in En | MEDLINE | ID: mdl-30012592
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Full text: 1 Database: MEDLINE Main subject: Transcription Factors / Transcription, Genetic / Nuclear Proteins / Triple Negative Breast Neoplasms / Neoplasm Proteins / Antineoplastic Agents Language: En Journal: Proc Natl Acad Sci U S A Year: 2018 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Transcription Factors / Transcription, Genetic / Nuclear Proteins / Triple Negative Breast Neoplasms / Neoplasm Proteins / Antineoplastic Agents Language: En Journal: Proc Natl Acad Sci U S A Year: 2018 Type: Article