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Dietary phytochemicals in breast cancer research: anticancer effects and potential utility for effective chemoprevention.
Kapinova, A; Kubatka, P; Golubnitschaja, O; Kello, M; Zubor, P; Solar, P; Pec, M.
Affiliation
  • Kapinova A; Division of Oncology, Biomedical Center Martin, Jessenius Faculty of Medicine, Comenius University in Bratislava, Malá Hora 4C, 036 01, Martin, Slovak Republic.
  • Kubatka P; Division of Oncology, Biomedical Center Martin, Jessenius Faculty of Medicine, Comenius University in Bratislava, Malá Hora 4C, 036 01, Martin, Slovak Republic.
  • Golubnitschaja O; Department of Medical Biology, Jessenius Faculty of Medicine, Comenius University in Bratislava, Malá Hora 4, 036 01, Martin, Slovak Republic.
  • Kello M; Radiological Clinic, Breast Cancer Research Center, Center for Integrated Oncology, Cologne-Bonn, Rheinische Friedrich-Wilhelms-Universität Bonn, Sigmund-Freud-Str 25, 53105, Bonn, Germany. Olga.Golubnitschaja@ukbonn.de.
  • Zubor P; Faculty of Medicine, Department of Pharmacology, University of Pavol Jozef Safárik, Trieda SNP 1, 040 11, Kosice, Slovak Republic.
  • Solar P; Division of Oncology, Biomedical Center Martin, Jessenius Faculty of Medicine, Comenius University in Bratislava, Malá Hora 4C, 036 01, Martin, Slovak Republic.
  • Pec M; Clinic of Gynecology and Obstetrics, Jessenius Faculty of Medicine, Comenius University in Bratislava, Kollárova 2, 03601, Martin, Slovak Republic.
Environ Health Prev Med ; 23(1): 36, 2018 Aug 09.
Article in En | MEDLINE | ID: mdl-30092754
Cancerous tissue transformation developing usually over years or even decades of life is a highly complex process involving strong stressors damaging DNA, chronic inflammation, comprehensive interaction between relevant molecular pathways, and cellular cross-talk within the neighboring tissues. Only the minor part of all cancer cases are caused by inborn predisposition; the absolute majority carry a sporadic character based on modifiable risk factors which play a central role in cancer prevention. Amongst most promising candidates for dietary supplements are bioactive phytochemicals demonstrating strong anticancer effects. Abundant evidence has been collected for beneficial effects of flavonoids, carotenoids, phenolic acids, and organosulfur compounds affecting a number of cancer-related pathways. Phytochemicals may positively affect processes of cell signaling, cell cycle regulation, oxidative stress response, and inflammation. They can modulate non-coding RNAs, upregulate tumor suppressive miRNAs, and downregulate oncogenic miRNAs that synergically inhibits cancer cell growth and cancer stem cell self-renewal. Potential clinical utility of the phytochemicals is discussed providing examples for chemoprevention against and therapy for human breast cancer. Expert recommendations are provided in the context of preventive medicine.
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Full text: 1 Database: MEDLINE Main subject: Breast Neoplasms / Anticarcinogenic Agents / Phytochemicals Type of study: Guideline / Prognostic_studies / Risk_factors_studies Language: En Journal: Environ Health Prev Med Year: 2018 Type: Article

Full text: 1 Database: MEDLINE Main subject: Breast Neoplasms / Anticarcinogenic Agents / Phytochemicals Type of study: Guideline / Prognostic_studies / Risk_factors_studies Language: En Journal: Environ Health Prev Med Year: 2018 Type: Article