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Targeted Structure-Activity Analysis of Endochin-like Quinolones Reveals Potent Qi and Qo Site Inhibitors of Toxoplasma gondii and Plasmodium falciparum Cytochrome bc1 and Identifies ELQ-400 as a Remarkably Effective Compound against Acute Experimental Toxoplasmosis.
McConnell, Erin V; Bruzual, Igor; Pou, Sovitj; Winter, Rolf; Dodean, Rozalia A; Smilkstein, Martin J; Krollenbrock, Alina; Nilsen, Aaron; Zakharov, Lev N; Riscoe, Michael K; Doggett, J Stone.
Affiliation
  • McConnell EV; VA Portland Health Care System Research and Development Service , 3710 SW US Veterans Hospital Road , Portland , Oregon 97239 , United States.
  • Bruzual I; VA Portland Health Care System Research and Development Service , 3710 SW US Veterans Hospital Road , Portland , Oregon 97239 , United States.
  • Pou S; VA Portland Health Care System Research and Development Service , 3710 SW US Veterans Hospital Road , Portland , Oregon 97239 , United States.
  • Winter R; VA Portland Health Care System Research and Development Service , 3710 SW US Veterans Hospital Road , Portland , Oregon 97239 , United States.
  • Dodean RA; VA Portland Health Care System Research and Development Service , 3710 SW US Veterans Hospital Road , Portland , Oregon 97239 , United States.
  • Smilkstein MJ; VA Portland Health Care System Research and Development Service , 3710 SW US Veterans Hospital Road , Portland , Oregon 97239 , United States.
  • Krollenbrock A; Oregon Health & Science University Department of Physiology and Pharmacology , 3181 SW Sam Jackson Park Road , Portland , Oregon 97239 , United States.
  • Nilsen A; VA Portland Health Care System Research and Development Service , 3710 SW US Veterans Hospital Road , Portland , Oregon 97239 , United States.
  • Zakharov LN; Department of Chemistry , University of Oregon , 1585 E 13th Avenue , Eugene , Oregon 97403 , United States.
  • Riscoe MK; VA Portland Health Care System Research and Development Service , 3710 SW US Veterans Hospital Road , Portland , Oregon 97239 , United States.
  • Doggett JS; Department of Molecular Microbiology & Immunology , Oregon Health & Science University , 3181 SW Sam Jackson Park Road , Portland , Oregon 97239 , United States.
ACS Infect Dis ; 4(11): 1574-1584, 2018 11 09.
Article in En | MEDLINE | ID: mdl-30117728
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Full text: 1 Database: MEDLINE Traditional Medicines: Medicinas_tradicionales_de_asia / Medicina_china Main subject: Phenyl Ethers / Plasmodium falciparum / Toxoplasma / Toxoplasmosis / Electron Transport Complex III / Quinolones / Antiprotozoal Agents Language: En Journal: ACS Infect Dis Year: 2018 Type: Article Affiliation country: United States
Fulltext
Add to My VHL
Print
XML
PubMed Links
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Full text: 1 Database: MEDLINE Traditional Medicines: Medicinas_tradicionales_de_asia / Medicina_china Main subject: Phenyl Ethers / Plasmodium falciparum / Toxoplasma / Toxoplasmosis / Electron Transport Complex III / Quinolones / Antiprotozoal Agents Language: En Journal: ACS Infect Dis Year: 2018 Type: Article Affiliation country: United States