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Oral administration of the LSD1 inhibitor ORY-3001 increases fetal hemoglobin in sickle cell mice and baboons.
Rivers, Angela; Vaitkus, Kestis; Jagadeeswaran, Ramasamy; Ruiz, Maria Armila; Ibanez, Vinzon; Ciceri, Filippo; Cavalcanti, Fernando; Molokie, Robert E; Saunthararajah, Yogen; Engel, James Douglas; DeSimone, Joseph; Lavelle, Donald.
Affiliation
  • Rivers A; Department of Pediatrics, University of Illinois at Chicago, Chicago, IL, USA; Jesse Brown VA Medical Center, Chicago, IL, USA.
  • Vaitkus K; Jesse Brown VA Medical Center, Chicago, IL, USA; Section of Hematology/Oncology, Department of Medicine, University of Illinois at Chicago, Chicago, IL, USA.
  • Jagadeeswaran R; Department of Pediatrics, University of Illinois at Chicago, Chicago, IL, USA; Jesse Brown VA Medical Center, Chicago, IL, USA.
  • Ruiz MA; Jesse Brown VA Medical Center, Chicago, IL, USA; Section of Hematology/Oncology, Department of Medicine, University of Illinois at Chicago, Chicago, IL, USA.
  • Ibanez V; Jesse Brown VA Medical Center, Chicago, IL, USA; Section of Hematology/Oncology, Department of Medicine, University of Illinois at Chicago, Chicago, IL, USA.
  • Ciceri F; Oryzon Genomics S.A., Barcelona, Spain.
  • Cavalcanti F; Oryzon Genomics S.A., Barcelona, Spain.
  • Molokie RE; Jesse Brown VA Medical Center, Chicago, IL, USA; Section of Hematology/Oncology, Department of Medicine, University of Illinois at Chicago, Chicago, IL, USA.
  • Saunthararajah Y; Department of Hematology and Oncology, Taussig Cancer Center, Cleveland Clinic, Cleveland, OH, USA.
  • Engel JD; Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI, USA.
  • DeSimone J; Section of Hematology/Oncology, Department of Medicine, University of Illinois at Chicago, Chicago, IL, USA.
  • Lavelle D; Jesse Brown VA Medical Center, Chicago, IL, USA; Section of Hematology/Oncology, Department of Medicine, University of Illinois at Chicago, Chicago, IL, USA. Electronic address: dlavelle@uic.edu.
Exp Hematol ; 67: 60-64.e2, 2018 11.
Article in En | MEDLINE | ID: mdl-30125603
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Full text: 1 Database: MEDLINE Main subject: Fetal Hemoglobin / Enzyme Inhibitors / Gamma-Globins / Histone Demethylases / Anemia, Sickle Cell Language: En Journal: Exp Hematol Year: 2018 Type: Article Affiliation country: United States
Fulltext
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Full text: 1 Database: MEDLINE Main subject: Fetal Hemoglobin / Enzyme Inhibitors / Gamma-Globins / Histone Demethylases / Anemia, Sickle Cell Language: En Journal: Exp Hematol Year: 2018 Type: Article Affiliation country: United States