Glycoside hydrolase family 18 and 20 enzymes are novel targets of the traditional medicine berberine.

Duan, Yanwei; Liu, Tian; Zhou, Yong; Dou, Tongyi; Yang, Qing

Duan, Yanwei; Liu, Tian; Zhou, Yong; Dou, Tongyi; Yang, Qing.

Affiliation

Duan Y; From the State Key Laboratory of Fine Chemical Engineering, School of Life Science and Biotechnology and School of Software, Dalian University of Technology, Dalian 116024.
Liu T; From the State Key Laboratory of Fine Chemical Engineering, School of Life Science and Biotechnology and School of Software, Dalian University of Technology, Dalian 116024, tianliu@dlut.edu.cn.
Zhou Y; From the State Key Laboratory of Fine Chemical Engineering, School of Life Science and Biotechnology and School of Software, Dalian University of Technology, Dalian 116024.
Dou T; the School of Life Science and Medicine, Dalian University of Technology, Panjin 124221, and.
Yang Q; From the State Key Laboratory of Fine Chemical Engineering, School of Life Science and Biotechnology and School of Software, Dalian University of Technology, Dalian 116024, qingyang@dlut.edu.cn.

J Biol Chem ; 293(40): 15429-15438, 2018 10 05.

Article in En | MEDLINE | ID: mdl-30135205

Subject(s)

Berberine/chemistry; Chitinases/chemistry; Glycoside Hydrolase Inhibitors/chemistry; Quinazolinones/chemistry; beta-N-Acetylhexosaminidases/chemistry; Animals; Berberine/metabolism; Binding Sites; Chitinases/antagonists & inhibitors; Chitinases/genetics; Chitinases/metabolism; Cloning, Molecular; Crystallography, X-Ray; Escherichia coli/genetics; Escherichia coli/metabolism; Gene Expression; Genetic Vectors/chemistry; Genetic Vectors/metabolism; Humans; Isoenzymes/antagonists & inhibitors; Isoenzymes/chemistry; Isoenzymes/genetics; Isoenzymes/metabolism; Kinetics; Medicine, Chinese Traditional/methods; Models, Molecular; Moths/chemistry; Moths/enzymology; Protein Binding; Protein Conformation, alpha-Helical; Protein Conformation, beta-Strand; Protein Interaction Domains and Motifs; Quinazolinones/metabolism; Recombinant Proteins/chemistry; Recombinant Proteins/genetics; Recombinant Proteins/metabolism; Saccharomyces cerevisiae/chemistry; Saccharomyces cerevisiae/enzymology; Static Electricity; Substrate Specificity; beta-N-Acetylhexosaminidases/antagonists & inhibitors; beta-N-Acetylhexosaminidases/genetics; beta-N-Acetylhexosaminidases/metabolism

Key words

berberine; chitinase; glycoside hydrolase; human; inhibitor; insect; protein crystallization; ß-N-acetyl-D-hexosaminidase

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Full text: 1 Database: MEDLINE Traditional Medicines: Medicinas_tradicionales_de_asia / Medicina_china Therapeutic Methods and Therapies TCIM: Plantas_medicinales Main subject: Berberine / Beta-N-Acetylhexosaminidases / Chitinases / Quinazolinones / Glycoside Hydrolase Inhibitors Type of study: Diagnostic_studies Language: En Journal: J Biol Chem Year: 2018 Type: Article

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