Protopanaxatriol inhibits melanin synthesis through inactivation of the pCREB-MITF-tyrosinase signalling pathway in melanocytes.

Lee, C-S; Nam, G-B; Park, J-S

Lee, C-S; Nam, G-B; Park, J-S.

Affiliation

Lee CS; Amorepacific CO R&D Center, Yongin-si, Korea.
Nam GB; Department of Beauty and Cosmetic Science, Eulji University, Seongnam-si, Korea.
Park JS; Amorepacific CO R&D Center, Yongin-si, Korea.

Clin Exp Dermatol ; 44(3): 295-299, 2019 Apr.

Article in En | MEDLINE | ID: mdl-30194867

Subject(s)

Cyclic AMP Response Element-Binding Protein/metabolism; Melanoma/metabolism; Microphthalmia-Associated Transcription Factor/metabolism; Sapogenins/pharmacology; Animals; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Gene Expression Regulation, Neoplastic/drug effects; Humans; Intramolecular Oxidoreductases/metabolism; Melanins/biosynthesis; Membrane Glycoproteins/metabolism; Mice; Oxidoreductases/metabolism; Sapogenins/chemistry; Signal Transduction/drug effects

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Full text: 1 Database: MEDLINE Main subject: Sapogenins / Cyclic AMP Response Element-Binding Protein / Microphthalmia-Associated Transcription Factor / Melanoma Language: En Journal: Clin Exp Dermatol Year: 2019 Type: Article

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