Genipin attenuates hyperoxia-induced lung injury and pulmonary hypertension via targeting glycogen synthase kinase-3 ß in neonatal rats.

Li, Jing; Shi, Jipeng; Li, Peiling; Guo, Xixia; Wang, Tuanjie; Liu, Aijuan

Li, Jing; Shi, Jipeng; Li, Peiling; Guo, Xixia; Wang, Tuanjie; Liu, Aijuan.

Affiliation

Li J; The Third Department of Pediatrics, The First Affiliated Hospital of Xinxiang Medical University, Weihui, China. Electronic address: Lijing32233@163.com.
Shi J; Neonatology Department, The First Affiliated Hospital of Xinxiang Medical University, Weihui, China.
Li P; The First Department of Pediatrics, The First Affiliated Hospital of Xinxiang Medical University, Weihui, China.
Guo X; The Third Department of Pediatrics, The First Affiliated Hospital of Xinxiang Medical University, Weihui, China.
Wang T; PICU, The First Affiliated Hospital of Xinxiang Medical University, Weihui, China.
Liu A; The Third Department of Pediatrics, The First Affiliated Hospital of Xinxiang Medical University, Weihui, China.

Nutrition ; 57: 237-244, 2019 01.

Article in En | MEDLINE | ID: mdl-30196116

Subject(s)

Bronchopulmonary Dysplasia/drug therapy; Gardenia/chemistry; Glycogen Synthase Kinase 3 beta/metabolism; Hypertension, Pulmonary/complications; Iridoids/therapeutic use; Lung Injury/prevention & control; Oxygen/metabolism; Animals; Animals, Newborn; Anti-Inflammatory Agents/pharmacology; Anti-Inflammatory Agents/therapeutic use; Antioxidants/pharmacology; Antioxidants/therapeutic use; Bronchopulmonary Dysplasia/etiology; Bronchopulmonary Dysplasia/metabolism; Disease Models, Animal; Humans; Hyperoxia/complications; Hypertension, Pulmonary/metabolism; Infant, Newborn; Interleukins/metabolism; Iridoids/pharmacology; Lung/drug effects; Lung/metabolism; Lung/pathology; Lung Injury/etiology; Lung Injury/metabolism; NF-E2-Related Factor 2/metabolism; NF-kappa B/metabolism; Phytotherapy; Plant Extracts/pharmacology; Plant Extracts/therapeutic use; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha/metabolism

Key words

Bronchopulmonary dysplasia; Genipin; Glycogen synthase kinase (GSK)-3 ß; Hyperoxia; Pulmonary hypertension

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Full text: 1 Database: MEDLINE Therapeutic Methods and Therapies TCIM: Terapias_biologicas / Aromoterapia Main subject: Oxygen / Bronchopulmonary Dysplasia / Gardenia / Iridoids / Lung Injury / Glycogen Synthase Kinase 3 beta / Hypertension, Pulmonary Type of study: Etiology_studies / Prognostic_studies Language: En Journal: Nutrition Year: 2019 Type: Article

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