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Discovery of a New Pterocarpan-Type Antineuroinflammatory Compound from Sophora tonkinensis through Suppression of the TLR4/NFκB/MAPK Signaling Pathway with PU.1 as a Potential Target.
Xia, Wenjuan; Luo, Pan; Hua, Pei; Ding, Peng; Li, Chanjuan; Xu, Jun; Zhou, Huihao; Gu, Qiong.
Affiliation
  • Xia W; Research Center for Drug Discovery, School of Pharmaceutical Sciences , Sun Yat-sen University , Guangzhou 510006 , People's Republic of China.
  • Luo P; Research Center for Drug Discovery, School of Pharmaceutical Sciences , Sun Yat-sen University , Guangzhou 510006 , People's Republic of China.
  • Hua P; Research Center for Drug Discovery, School of Pharmaceutical Sciences , Sun Yat-sen University , Guangzhou 510006 , People's Republic of China.
  • Ding P; Research Center for Drug Discovery, School of Pharmaceutical Sciences , Sun Yat-sen University , Guangzhou 510006 , People's Republic of China.
  • Li C; Research Center for Drug Discovery, School of Pharmaceutical Sciences , Sun Yat-sen University , Guangzhou 510006 , People's Republic of China.
  • Xu J; Research Center for Drug Discovery, School of Pharmaceutical Sciences , Sun Yat-sen University , Guangzhou 510006 , People's Republic of China.
  • Zhou H; Research Center for Drug Discovery, School of Pharmaceutical Sciences , Sun Yat-sen University , Guangzhou 510006 , People's Republic of China.
  • Gu Q; Research Center for Drug Discovery, School of Pharmaceutical Sciences , Sun Yat-sen University , Guangzhou 510006 , People's Republic of China.
ACS Chem Neurosci ; 10(1): 295-303, 2019 01 16.
Article in En | MEDLINE | ID: mdl-30223643
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Full text: 1 Database: MEDLINE Main subject: Trans-Activators / NF-kappa B / Proto-Oncogene Proteins / Mitogen-Activated Protein Kinases / Sophora / Pterocarpans / Toll-Like Receptor 4 / Anti-Inflammatory Agents Type of study: Prognostic_studies Language: En Journal: ACS Chem Neurosci Year: 2019 Type: Article
Fulltext
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Full text: 1 Database: MEDLINE Main subject: Trans-Activators / NF-kappa B / Proto-Oncogene Proteins / Mitogen-Activated Protein Kinases / Sophora / Pterocarpans / Toll-Like Receptor 4 / Anti-Inflammatory Agents Type of study: Prognostic_studies Language: En Journal: ACS Chem Neurosci Year: 2019 Type: Article