AuNPs-PCL nanocomposite accelerated abdominal wound healing through photothermal effect and improving cell adhesion.
J Biomater Sci Polym Ed
; 29(16): 2035-2049, 2018 11.
Article
in En
| MEDLINE
| ID: mdl-30235107
ABSTRACT
Accelerating wound healing with modified biomaterial has been an attracting field in both material science and medicine. Enhanced cell adhesion could be acquired by improving surface hydrophilicity, which contributes to accelerating wound healing. Chemical reaction has been used for surface modification, but this study used a simple and nontoxic method to improve the hydrophilicity. Polycaprolactone (PCL) scaffold has been regarded as promising material for wound healing while its surface is hydrophobic. Our study demonstrated enhanced hydrophilicity of PCL with AuNPs coating. AuNPs has good biocompatibility and excellent photothermal effect. The coating of AuNPs not only improved the cell adhesion, but also gave PCL the ability to inhibit the growth of bacteria. Animal study showed that the nanocomposites decreased lymphocytes and neutrophils, increased neovascularization and accelerated the abdominal wound healing, which was attributed to improved hydrophilicity and the antibacterial ability. In conclusion, we demonstrated that the nanocomposite could be used as a potential scaffold for cell adhesion and wound healing, and the role of AuNPs was highlighted as a kind of outstanding supplement.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Polyesters
/
Wound Healing
/
Nanocomposites
/
Metal Nanoparticles
/
Gold
/
Anti-Bacterial Agents
Language:
En
Journal:
J Biomater Sci Polym Ed
Year:
2018
Type:
Article
Affiliation country:
China