Chitosan/alginate nanoparticles as a promising approach for oral delivery of curcumin diglutaric acid for cancer treatment.
Mater Sci Eng C Mater Biol Appl
; 93: 178-190, 2018 Dec 01.
Article
in En
| MEDLINE
| ID: mdl-30274050
ABSTRACT
Curcumin diglutaric acid (CG) is a prodrug of curcumin that shows better solubility and antinociceptive activity compared to curcumin. To improve its properties further, CG was encapsulated into polysaccharide-based nanoparticles in this study. A chitosan/alginate nanoparticulate system was chosen for encapsulation of CG due to its biocompatibility, biodegradability, non-toxicity, mucoadhisiveness and good film formation. CG-loaded chitosan/alginate nanoparticles were prepared by o/w emulsification and ionotropic gelification, with the conditions optimized using response surface methodology. A chitosan/alginate mass ratio of 0.041, CG concentration of 3â¯mg/mL and Pluronic®F127 concentration of 0.50% (w/v) were determined to be optimal for the nanoparticle preparation. FTIR and XRD confirmed encapsulation of CG into the chitosan/alginate nanoparticles. The CG-loaded chitosan/alginate nanoparticles showed better stability under UV radiation and in a simulated gastrointestinal environment, compared to a CG dispersion in water. The nanoparticles showed slow cumulative release of CG in simulated gastrointestinal fluids without enzymes and in body fluid. A Weibull model of the best fit for all conditions suggested that the release pattern of CG from CG-loaded chitosan/alginate nanoparticles was mainly controlled by Fickian diffusion and erosion of polymer materials. Finally, CG-loaded chitosan/alginate nanoparticles showed higher in vitro cellular uptake in human epithelial colorectal adenocarcinoma (Caco-2 cells) and better anticancer activity against Caco-2, human hepatocellular carcinoma (HepG2) and human breast cancer (MDA-MB-231) cells. Therefore, the CG-loaded chitosan/alginate nanoparticles are a promising approach for oral administration of CG for cancer treatment.
Key words
Full text:
1
Database:
MEDLINE
Therapeutic Methods and Therapies TCIM:
Terapias_biologicas
/
Aromoterapia
/
Plantas_medicinales
Main subject:
Prodrugs
/
Curcumin
/
Chitosan
/
Alginates
/
Nanoparticles
/
Neoplasms
/
Antineoplastic Agents
Language:
En
Journal:
Mater Sci Eng C Mater Biol Appl
Year:
2018
Type:
Article
Affiliation country:
Thailand