Bitter Taste Receptor Ligand Improves Metabolic and Reproductive Functions in a Murine Model of PCOS.

Wu, Sheng; Xue, Ping; Grayson, Neile; Bland, Jeffrey S; Wolfe, Andrew

Wu, Sheng; Xue, Ping; Grayson, Neile; Bland, Jeffrey S; Wolfe, Andrew.

Affiliation

Wu S; Division of Endocrinology, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Xue P; Division of Endocrinology, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Grayson N; Kindex Pharmaceutical, Bainbridge Island, Washington.
Bland JS; Kindex Pharmaceutical, Bainbridge Island, Washington.
Wolfe A; Division of Endocrinology, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland.

Endocrinology ; 160(1): 143-155, 2019 01 01.

Article in En | MEDLINE | ID: mdl-30418546

Subject(s)

Plant Extracts/administration & dosage; Polycystic Ovary Syndrome/drug therapy; Polycystic Ovary Syndrome/metabolism; Receptors, G-Protein-Coupled/agonists; Adiposity/drug effects; Androstenedione/metabolism; Animals; Cytochrome P450 Family 17/genetics; Cytochrome P450 Family 17/metabolism; Disease Models, Animal; Estrous Cycle/drug effects; Female; Humans; Humulus/chemistry; Ligands; Mice; Mice, Inbred C57BL; Plant Extracts/chemistry; Polycystic Ovary Syndrome/genetics; Polycystic Ovary Syndrome/physiopathology; Receptors, G-Protein-Coupled/genetics; Receptors, G-Protein-Coupled/metabolism; Testosterone/metabolism

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Full text: 1 Database: MEDLINE Main subject: Polycystic Ovary Syndrome / Plant Extracts / Receptors, G-Protein-Coupled Language: En Journal: Endocrinology Year: 2019 Type: Article

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