Anti-Colitic Effects of Ethanol Extract of <i>Persea americana</i> Mill. through Suppression of Pro-Inflammatory Mediators via NF-&#954;B/STAT3 Inactivation in Dextran Sulfate Sodium-Induced Colitis Mice.

Hong, Joo Young; Chung, Kyung-Sook; Shin, Ji-Sun; Park, Geonha; Jang, Young Pyo; Lee, Kyung-Tae

Anti-Colitic Effects of Ethanol Extract of Persea americana Mill. through Suppression of Pro-Inflammatory Mediators via NF-κB/STAT3 Inactivation in Dextran Sulfate Sodium-Induced Colitis Mice.

Hong, Joo Young; Chung, Kyung-Sook; Shin, Ji-Sun; Park, Geonha; Jang, Young Pyo; Lee, Kyung-Tae.

Affiliation

Hong JY; Department of Pharmaceutical Biochemistry, College of Pharmacy, Kyung Hee University, 26, Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Korea. hjisuk1206@naver.com.
Chung KS; Department of Life and Nanopharmaceutical Sciences, Graduate School, Kyung Hee University, 26, Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Korea. hjisuk1206@naver.com.
Shin JS; Department of Pharmaceutical Biochemistry, College of Pharmacy, Kyung Hee University, 26, Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Korea. adella76@hanmail.net.
Park G; Department of Pharmaceutical Biochemistry, College of Pharmacy, Kyung Hee University, 26, Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Korea. jsshin@khu.ac.kr.
Jang YP; Department of Life and Nanopharmaceutical Sciences, Graduate School, Kyung Hee University, 26, Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Korea. ginapark0326@khu.ac.kr.
Lee KT; Department of Life and Nanopharmaceutical Sciences, Graduate School, Kyung Hee University, 26, Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Korea. ypjang@khu.ac.kr.

Int J Mol Sci ; 20(1)2019 Jan 05.

Article in En | MEDLINE | ID: mdl-30621304

Subject(s)

Colitis/drug therapy; Ethanol/chemistry; Inflammation Mediators/metabolism; NF-kappa B/metabolism; Persea/chemistry; Plant Extracts/therapeutic use; STAT3 Transcription Factor/metabolism; Signal Transduction; Animals; Colitis/chemically induced; Colitis/pathology; Cyclooxygenase 2/metabolism; Cytokines/genetics; Cytokines/metabolism; Dextran Sulfate; Dinoprostone/biosynthesis; Flavonoids/analysis; Lipopolysaccharides; Macrophages/drug effects; Macrophages/metabolism; Mice; Nitric Oxide/biosynthesis; Nitric Oxide Synthase Type II/metabolism; Phytochemicals/analysis; Plant Extracts/pharmacology; Polyphenols/analysis; RAW 264.7 Cells; RNA, Messenger/genetics; RNA, Messenger/metabolism

Key words

DSS; NF-κB; Persea americana Mill.; STAT3; anti-inflammation; avocado; macrophage

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Full text: 1 Database: MEDLINE Therapeutic Methods and Therapies TCIM: Terapias_biologicas / Plantas_medicinales Main subject: Plant Extracts / Signal Transduction / NF-kappa B / Colitis / Inflammation Mediators / Persea / Ethanol / STAT3 Transcription Factor Language: En Journal: Int J Mol Sci Year: 2019 Type: Article

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