Discovery of novel hit compounds with broad activity against visceral and cutaneous Leishmania species by comparative phenotypic screening.

Lamotte, S; Aulner, N; Späth, G F; Prina, E

Lamotte, S; Aulner, N; Späth, G F; Prina, E.

Affiliation

Lamotte S; Institut Pasteur, Molecular Parasitology and Signaling, INSERM U1201, Department of Parasites and Insect Vectors, Paris, France.
Aulner N; Institut Pasteur, UTechS Photonic BioImaging, Center for Technological Research and Resources, 75015, Paris, France.
Späth GF; Institut Pasteur, Molecular Parasitology and Signaling, INSERM U1201, Department of Parasites and Insect Vectors, Paris, France. gerald.spaeth@pasteur.fr.
Prina E; Institut Pasteur, Molecular Parasitology and Signaling, INSERM U1201, Department of Parasites and Insect Vectors, Paris, France. eric.prina@pasteur.fr.

Sci Rep ; 9(1): 438, 2019 01 24.

Article in En | MEDLINE | ID: mdl-30679614

Subject(s)

Antiprotozoal Agents/pharmacology; Drug Evaluation, Preclinical/methods; Leishmania donovani/drug effects; Leishmania mexicana/drug effects; Leishmaniasis, Cutaneous/prevention & control; Leishmaniasis, Visceral/prevention & control; Animals; Antiprotozoal Agents/chemistry; Cells, Cultured; Humans; Leishmania donovani/pathogenicity; Leishmania mexicana/pathogenicity; Leishmaniasis, Cutaneous/parasitology; Leishmaniasis, Visceral/parasitology; Macrophages/drug effects; Macrophages/parasitology; Mice, Inbred BALB C; Molecular Structure; Phenotype; Species Specificity; THP-1 Cells; Virulence/drug effects

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Full text: 1 Database: MEDLINE Main subject: Leishmania donovani / Leishmania mexicana / Leishmaniasis, Cutaneous / Drug Evaluation, Preclinical / Leishmaniasis, Visceral / Antiprotozoal Agents Type of study: Diagnostic_studies / Screening_studies Language: En Journal: Sci Rep Year: 2019 Type: Article Affiliation country: France

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