Link between the unfolded protein response and dysregulation of mitochondrial bioenergetics in Alzheimer's disease.

Poirier, Yannik; Grimm, Amandine; Schmitt, Karen; Eckert, Anne

Poirier, Yannik; Grimm, Amandine; Schmitt, Karen; Eckert, Anne.

Affiliation

Poirier Y; Transfaculty Research Platform, Molecular and Cognitive Neuroscience, University of Basel, Basel, Switzerland.
Grimm A; Neurobiology Laboratory for Brain Aging and Mental Health, Psychiatric University Clinics Basel, Basel, Switzerland.
Schmitt K; Transfaculty Research Platform, Molecular and Cognitive Neuroscience, University of Basel, Basel, Switzerland.
Eckert A; Neurobiology Laboratory for Brain Aging and Mental Health, Psychiatric University Clinics Basel, Basel, Switzerland.

Cell Mol Life Sci ; 76(7): 1419-1431, 2019 Apr.

Article in En | MEDLINE | ID: mdl-30683981

Subject(s)

Alzheimer Disease/pathology; Energy Metabolism/physiology; Mitochondria/metabolism; Unfolded Protein Response; Adenosine Triphosphate/metabolism; Alzheimer Disease/metabolism; Amyloid beta-Peptides/metabolism; Amyloid beta-Protein Precursor/genetics; Amyloid beta-Protein Precursor/metabolism; Cell Line, Tumor; Cell Survival/drug effects; Down-Regulation/drug effects; Endoplasmic Reticulum Stress/drug effects; Humans; Membrane Potential, Mitochondrial/drug effects; Mutagenesis, Site-Directed; Thapsigargin/pharmacology; Unfolded Protein Response/drug effects; Up-Regulation/drug effects; tau Proteins/genetics; tau Proteins/metabolism

Key words

Alzheimer's disease; Amyloid-ß peptide; ER stress; Mitochondrial dysfunction; Tau protein; Unfolded protein response

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Full text: 1 Database: MEDLINE Therapeutic Methods and Therapies TCIM: Terapias_energeticas / Bioenergetica Main subject: Energy Metabolism / Unfolded Protein Response / Alzheimer Disease / Mitochondria Language: En Journal: Cell Mol Life Sci Year: 2019 Type: Article Affiliation country: Switzerland

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