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The hypothetical impact of Accelerate Pheno™ system on time to effective therapy and time to definitive therapy in an institution with an established antimicrobial stewardship programme currently utilizing rapid genotypic organism/resistance marker identification.
Henig, Oryan; Cooper, Christopher C; Kaye, Keith S; Lephart, Paul; Salimnia, Hossein; Taylor, Maureen; Hussain, Noman; Hussain, Zara; Deeds, Kathryn; Hayat, Umar; Patel, Jinit; Pogue, Jason M.
Affiliation
  • Henig O; University of Michigan Medical School, Ann Arbor, MI, USA.
  • Cooper CC; Michigan State University, East Lansing, MI, USA.
  • Kaye KS; University of Michigan Medical School, Ann Arbor, MI, USA.
  • Lephart P; University of Michigan Medical School, Ann Arbor, MI, USA.
  • Salimnia H; Wayne State University, Detroit, MI, USA.
  • Taylor M; Detroit Medical Center, Detroit, MI.
  • Hussain N; Detroit Medical Center, Detroit, MI.
  • Hussain Z; Henry Ford Health System, Detroit, MI, USA.
  • Deeds K; Detroit Medical Center, Detroit, MI.
  • Hayat U; Wayne State University, Detroit, MI, USA.
  • Patel J; Detroit Medical Center, Detroit, MI.
  • Pogue JM; Detroit Medical Center, Detroit, MI.
J Antimicrob Chemother ; 74(Suppl 1): i32-i39, 2019 01 01.
Article in En | MEDLINE | ID: mdl-30690538
Background: Rapid organism identification and antimicrobial susceptibility testing (AST) can optimize antimicrobial therapy in patients with bacteraemia. The Accelerate Pheno™ system (ACC) can provide identification and AST results within 7 h of a positive culture. Objectives: To assess the hypothetical impact of ACC on time to effective therapy (TTET), time to definitive therapy (TTDT) and antimicrobial usage at the Detroit Medical Center (DMC). Methods: Patients with positive blood cultures from 29 March to 24 June 2016 were included. ACC was performed in parallel with normal laboratory procedures, but results were not made available to the clinicians. The potential benefit of having ACC results was determined if clinicians modified therapy based on actual AST results. Potential changes in TTET, TTDT and antibiotic usage were calculated. Results: One hundred and sixty-seven patients were included. The median TTET was 2.4 h (IQR 0.5, 15.1). Had ACC results been available, TTET could have been improved in four patients (2.4%), by a median decrease of 18.9 h (IQR 11.3, 20.4). The median TTDT was 41.4 h (IQR 21.7, 73.3) and ACC results could have improved TTDT among 51 patients (30.5%), by a median decrease of 25.4 h (IQR 18.7, 37.5). ACC implementation could have led to decreases in usage of cefepime (16% reduction), aminoglycosides (23%), piperacillin/tazobactam (8%) and vancomycin (4%). Conclusions: ACC results could potentially improve time to de-escalation and reduce use of antimicrobials. The impact of ACC on TTET was small, likely related to the availability of other rapid diagnostic tests at DMC.
Subject(s)

Full text: 1 Database: MEDLINE Therapeutic Methods and Therapies TCIM: Plantas_medicinales Main subject: Gram-Negative Bacterial Infections / Drug Resistance, Multiple, Bacterial / Time-to-Treatment / Antimicrobial Stewardship / Gram-Negative Bacteria / Anti-Bacterial Agents Type of study: Diagnostic_studies / Observational_studies / Prognostic_studies Language: En Journal: J Antimicrob Chemother Year: 2019 Type: Article Affiliation country: United States

Full text: 1 Database: MEDLINE Therapeutic Methods and Therapies TCIM: Plantas_medicinales Main subject: Gram-Negative Bacterial Infections / Drug Resistance, Multiple, Bacterial / Time-to-Treatment / Antimicrobial Stewardship / Gram-Negative Bacteria / Anti-Bacterial Agents Type of study: Diagnostic_studies / Observational_studies / Prognostic_studies Language: En Journal: J Antimicrob Chemother Year: 2019 Type: Article Affiliation country: United States