Validation of an LC-MS/MS method for simultaneous detection of diverse components of Qinxing Qingre Zhike Granule in rat plasma and its application to pharmacokinetic study after oral administration to rats.

Wang, Zilingyun; An, Rui; Du, Guangli; Liang, Kun; Li, Guowen

Wang, Zilingyun; An, Rui; Du, Guangli; Liang, Kun; Li, Guowen.

Affiliation

Wang Z; Shanghai University of Traditional Chinese Medicine, Shanghai, China.
An R; Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Du G; Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Liang K; Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Li G; Shanghai Hospital of Integrated Traditional Chinese and Western Medicine, Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Biomed Chromatogr ; 33(7): e4524, 2019 Jul.

Article in En | MEDLINE | ID: mdl-30821835

Subject(s)

Chromatography, Liquid/methods; Drugs, Chinese Herbal/pharmacokinetics; Flavonoids/blood; Tandem Mass Spectrometry/methods; Administration, Oral; Animals; Drugs, Chinese Herbal/administration & dosage; Flavanones; Flavonoids/chemistry; Flavonoids/pharmacokinetics; Glucosides; Limit of Detection; Linear Models; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Triterpenes/blood; Triterpenes/chemistry; Triterpenes/pharmacokinetics

Key words

LC-MS/MS; Qinxing Qingre Zhike granule; pharmacokinetics; rat plasma

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Full text: 1 Database: MEDLINE Traditional Medicines: Medicinas_tradicionales_de_asia / Medicina_china Main subject: Flavonoids / Drugs, Chinese Herbal / Chromatography, Liquid / Tandem Mass Spectrometry Type of study: Diagnostic_studies / Prognostic_studies Language: En Journal: Biomed Chromatogr Year: 2019 Type: Article Affiliation country: China

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