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New lectin ligands: Testing of Amadori rearrangement products with a series of mannoside-specific lectins.
Prasch, Herwig; Hojnik, Cornelia; Lindhorst, Thisbe K; Didak, Blanka; Landemarre, Ludovic; Wrodnigg, Tanja M.
Affiliation
  • Prasch H; Glycogroup, Institute of Organic Chemistry, Graz University of Technology, Stremayrgasse 9, A-8010, Graz, Austria.
  • Hojnik C; Glycogroup, Institute of Organic Chemistry, Graz University of Technology, Stremayrgasse 9, A-8010, Graz, Austria.
  • Lindhorst TK; Christiana Albertina University of Kiel, Otto Diels Institute of Organic Chemistry, Otto-Hahn-Platz 3-4, D-24118, Kiel, Germany.
  • Didak B; GLYcoDiag, 45520, Chevilly, France.
  • Landemarre L; GLYcoDiag, 45520, Chevilly, France.
  • Wrodnigg TM; Glycogroup, Institute of Organic Chemistry, Graz University of Technology, Stremayrgasse 9, A-8010, Graz, Austria. Electronic address: t.wrodnigg@tugraz.at.
Carbohydr Res ; 475: 65-68, 2019 Mar 01.
Article in En | MEDLINE | ID: mdl-30844665
1-(N-Phenyl)amino-1-deoxy-α-D-manno-hept-2-ulose (2) and two multivalent BSA-based structures 7 and 8, d-manno-configured C-glycosyl-type compounds derived from an Amadori rearrangement, were evaluated as ligands for mannoside-specific lectins of various sources. The determination of the concentration corresponding to 50% of inhibition (IC50) is described. Multivalency turned out to effectively influence ligand selectivity and lectin binding.
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Full text: 1 Database: MEDLINE Main subject: Lectins / Mannosides / Anti-Bacterial Agents Language: En Journal: Carbohydr Res Year: 2019 Type: Article Affiliation country: Austria
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Full text: 1 Database: MEDLINE Main subject: Lectins / Mannosides / Anti-Bacterial Agents Language: En Journal: Carbohydr Res Year: 2019 Type: Article Affiliation country: Austria