Effect of lifelong carnitine supplementation on plasma and tissue carnitine status, hepatic lipid metabolism and stress signalling pathways and skeletal muscle transcriptome in mice at advanced age.

Cheema, Uzman B; Most, Erika; Eder, Klaus; Ringseis, Robert

Cheema, Uzman B; Most, Erika; Eder, Klaus; Ringseis, Robert.

Affiliation

Cheema UB; Institute of Animal Nutrition and Nutrition Physiology,Justus-Liebig-University Giessen,Heinrich-Buff-Ring 26-32,35392 Giessen,Germany.
Most E; Institute of Animal Nutrition and Nutrition Physiology,Justus-Liebig-University Giessen,Heinrich-Buff-Ring 26-32,35392 Giessen,Germany.
Eder K; Institute of Animal Nutrition and Nutrition Physiology,Justus-Liebig-University Giessen,Heinrich-Buff-Ring 26-32,35392 Giessen,Germany.
Ringseis R; Institute of Animal Nutrition and Nutrition Physiology,Justus-Liebig-University Giessen,Heinrich-Buff-Ring 26-32,35392 Giessen,Germany.

Br J Nutr ; 121(12): 1323-1333, 2019 06.

Article in En | MEDLINE | ID: mdl-30935426

Subject(s)

Carnitine/pharmacology; Dietary Supplements; Lipid Metabolism/drug effects; Signal Transduction/drug effects; Transcriptome/drug effects; Animals; Carnitine/blood; Liver/metabolism; Mice; Muscle, Skeletal/metabolism

Key words

Aldh9a1 aldehyde dehydrogenase 9 family member A1; Ankrd2 ankyrin repeat domain 2; B4galnt2 ß-1; Bbox1 Î³-butyrobetaine hydroxylase 1; Octn2 organic cation transporter 2; Olfr olfactory receptor; Î³-BB Î³-butyrobetaine; BW body weight; ER endoplasmic reticulum; FC fold change; GO gene ontology; GSEA gene set enrichment analysis; SREBP sterol regulatory element-binding protein; qPCR quantitative real-time PCR; 4-N-acetylgalactosaminyltransferase 2; Aged mice; Carnitine supplementation; Liver; Skeletal muscle

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Full text: 1 Database: MEDLINE Main subject: Carnitine / Signal Transduction / Dietary Supplements / Lipid Metabolism / Transcriptome Language: En Journal: Br J Nutr Year: 2019 Type: Article Affiliation country: Germany

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