Repurposing disulfiram for treatment of Staphylococcus aureus infections.

Thakare, Ritesh; Shukla, Manjulika; Kaul, Grace; Dasgupta, Arunava; Chopra, Sidharth

Thakare, Ritesh; Shukla, Manjulika; Kaul, Grace; Dasgupta, Arunava; Chopra, Sidharth.

Affiliation

Thakare R; Division of Microbiology, Central Drug Research Institute, Uttar Pradesh, India.
Shukla M; Division of Microbiology, Central Drug Research Institute, Uttar Pradesh, India.
Kaul G; Division of Microbiology, Central Drug Research Institute, Uttar Pradesh, India.
Dasgupta A; Division of Microbiology, Central Drug Research Institute, Uttar Pradesh, India. Electronic address: a.dasgupta@cdri.res.in.
Chopra S; Division of Microbiology, Central Drug Research Institute, Uttar Pradesh, India. Electronic address: Skchopra007@gmail.com.

Int J Antimicrob Agents ; 53(6): 709-715, 2019 Jun.

Article in En | MEDLINE | ID: mdl-30954635

Subject(s)

Alcohol Deterrents/pharmacology; Anti-Bacterial Agents/pharmacology; Disulfiram/pharmacology; Staphylococcal Infections/drug therapy; Staphylococcus aureus/drug effects; Alcohol Deterrents/therapeutic use; Animals; Anti-Bacterial Agents/therapeutic use; Chlorocebus aethiops; Disease Models, Animal; Disulfiram/therapeutic use; Drug Evaluation, Preclinical; Mice, Inbred BALB C; Microbial Sensitivity Tests; Staphylococcal Infections/microbiology; Therapeutic Index, Drug; Treatment Outcome; Vero Cells

Key words

Disulfiram; Drug resistance; Metabolic enzyme; Staphylococcus aureus

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Full text: 1 Database: MEDLINE Therapeutic Methods and Therapies TCIM: Plantas_medicinales Main subject: Staphylococcal Infections / Staphylococcus aureus / Disulfiram / Alcohol Deterrents / Anti-Bacterial Agents Type of study: Prognostic_studies Language: En Journal: Int J Antimicrob Agents Year: 2019 Type: Article Affiliation country: India

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