A DNMT3A PWWP mutation leads to methylation of bivalent chromatin and growth retardation in mice.

Sendzikaite, Gintare; Hanna, Courtney W; Stewart-Morgan, Kathleen R; Ivanova, Elena; Kelsey, Gavin

Sendzikaite, Gintare; Hanna, Courtney W; Stewart-Morgan, Kathleen R; Ivanova, Elena; Kelsey, Gavin.

Affiliation

Sendzikaite G; Epigenetics Programme, Babraham Institute, Cambridge, CB22 3AT, UK.
Hanna CW; Epigenetics Programme, Babraham Institute, Cambridge, CB22 3AT, UK.
Stewart-Morgan KR; Centre for Trophoblast Research, University of Cambridge, Cambridge, CB2 3EG, UK.
Ivanova E; Epigenetics Programme, Babraham Institute, Cambridge, CB22 3AT, UK.
Kelsey G; Biotech Research & Innovation Centre, 2200, Copenhagen, Denmark.

Nat Commun ; 10(1): 1884, 2019 04 23.

Article in En | MEDLINE | ID: mdl-31015495

Subject(s)

Chromatin/metabolism; DNA (Cytosine-5-)-Methyltransferases/genetics; DNA Methylation/physiology; Gene Expression Regulation, Developmental; Growth Disorders/genetics; Animals; Animals, Newborn; DNA Methyltransferase 3A; Disease Models, Animal; Female; Gain of Function Mutation/physiology; Growth Disorders/pathology; Histones/metabolism; Humans; Hypothalamus/metabolism; Hypothalamus/pathology; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Point Mutation/physiology; Protein Binding/genetics; Protein Domains/genetics; Protein Processing, Post-Translational/physiology

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Full text: 1 Database: MEDLINE Main subject: Chromatin / Gene Expression Regulation, Developmental / DNA Methylation / DNA (Cytosine-5-)-Methyltransferases / Growth Disorders Language: En Journal: Nat Commun Year: 2019 Type: Article Affiliation country: United kingdom

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