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Phenotypic screening of nonsteroidal anti-inflammatory drugs identified mefenamic acid as a drug for the treatment of schistosomiasis.
Lago, Eloi M; Silva, Marcos P; Queiroz, Talita G; Mazloum, Susana F; Rodrigues, Vinícius C; Carnaúba, Paulo U; Pinto, Pedro L; Rocha, Jefferson A; Ferreira, Leonardo L G; Andricopulo, Adriano D; de Moraes, Josué.
Affiliation
  • Lago EM; Research Center for Neglected Diseases, University of Guarulhos, Praça Tereza Cristina, 229, Centro, 07023-070, Guarulhos, SP, Brazil.
  • Silva MP; Research Center for Neglected Diseases, University of Guarulhos, Praça Tereza Cristina, 229, Centro, 07023-070, Guarulhos, SP, Brazil.
  • Queiroz TG; Research Center for Neglected Diseases, University of Guarulhos, Praça Tereza Cristina, 229, Centro, 07023-070, Guarulhos, SP, Brazil.
  • Mazloum SF; Research Center for Neglected Diseases, University of Guarulhos, Praça Tereza Cristina, 229, Centro, 07023-070, Guarulhos, SP, Brazil.
  • Rodrigues VC; Research Center for Neglected Diseases, University of Guarulhos, Praça Tereza Cristina, 229, Centro, 07023-070, Guarulhos, SP, Brazil.
  • Carnaúba PU; Research Center for Neglected Diseases, University of Guarulhos, Praça Tereza Cristina, 229, Centro, 07023-070, Guarulhos, SP, Brazil.
  • Pinto PL; Center for Research in Parasitology, Adolfo Lutz Institute, São Paulo, SP, Brazil.
  • Rocha JA; Research Group of Natural Science and Biotechnology, Federal University of Maranhão, Grajaú, MA, Brazil.
  • Ferreira LLG; Laboratory of Medicinal and Computational Chemistry, Center for Research and Innovation in Biodiversity and Drug Discovery, Physics Institute of Sao Carlos, University of Sao Paulo, São Carlos, SP, Brazil.
  • Andricopulo AD; Laboratory of Medicinal and Computational Chemistry, Center for Research and Innovation in Biodiversity and Drug Discovery, Physics Institute of Sao Carlos, University of Sao Paulo, São Carlos, SP, Brazil.
  • de Moraes J; Research Center for Neglected Diseases, University of Guarulhos, Praça Tereza Cristina, 229, Centro, 07023-070, Guarulhos, SP, Brazil. Electronic address: josuem@usp.br.
EBioMedicine ; 43: 370-379, 2019 May.
Article in En | MEDLINE | ID: mdl-31027918
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Full text: 1 Database: MEDLINE Main subject: Schistosoma / Schistosomicides / Anti-Inflammatory Agents, Non-Steroidal / Mefenamic Acid / Parasitic Sensitivity Tests Type of study: Diagnostic_studies / Prognostic_studies / Screening_studies Language: En Journal: EBioMedicine Year: 2019 Type: Article Affiliation country: Brazil
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Full text: 1 Database: MEDLINE Main subject: Schistosoma / Schistosomicides / Anti-Inflammatory Agents, Non-Steroidal / Mefenamic Acid / Parasitic Sensitivity Tests Type of study: Diagnostic_studies / Prognostic_studies / Screening_studies Language: En Journal: EBioMedicine Year: 2019 Type: Article Affiliation country: Brazil