Repurposing of Fluvastatin Against Candida albicans CYP450 Lanosterol 14 &#945;-demethylase, a Target Enzyme for Antifungal Therapy: An In silico and In vitro Study.

Rana, Ritika; Sharma, Ruchika; Kumar, Anoop

Repurposing of Fluvastatin Against Candida albicans CYP450 Lanosterol 14 α-demethylase, a Target Enzyme for Antifungal Therapy: An In silico and In vitro Study.

Rana, Ritika; Sharma, Ruchika; Kumar, Anoop.

Affiliation

Rana R; Department of Pharmacology, Indo-Soviet Friendship Pharmacy College (ISFCP), Moga, Punjab, India.
Sharma R; Department of Biotechnology, Indo-Soviet Friendship College of Professional Studies (ISFCPS), Moga, Punjab, India.
Kumar A; Department of Pharmacology, Indo-Soviet Friendship Pharmacy College (ISFCP), Moga, Punjab, India.

Curr Mol Med ; 19(7): 506-524, 2019.

Article in En | MEDLINE | ID: mdl-31109273

Subject(s)

Candida albicans/drug effects; Candidiasis/drug therapy; Fluvastatin/pharmacology; Sterol 14-Demethylase/genetics; Animals; Antifungal Agents/pharmacology; Candida albicans/pathogenicity; Candidiasis/genetics; Candidiasis/microbiology; Computational Biology; Drug Repositioning; Fluvastatin/chemistry; Humans; Mice; Microbial Sensitivity Tests; Sterol 14-Demethylase/drug effects

Key words

Candida albicans; docking study; ex vivo study; fluvastatin; homologous model; in vitro study.

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Full text: 1 Database: MEDLINE Therapeutic Methods and Therapies TCIM: Plantas_medicinales Main subject: Candida albicans / Candidiasis / Sterol 14-Demethylase / Fluvastatin Language: En Journal: Curr Mol Med Year: 2019 Type: Article Affiliation country: India

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