(Nva2)-cyclosporine--less potent than cyclosporine A in rats with lung and heart transplants.
Transplantation
; 44(1): 5-8, 1987 Jul.
Article
in En
| MEDLINE
| ID: mdl-3111038
ABSTRACT
The ability of a new cyclosporine (Cs) derivative, (Nva2)-Cs (CsG), to suppress rejection of lung and heart allografts in rats was determined and compared with that of CsA. Left lungs were transplanted orthotopically; hearts were transplanted heterotopically into the abdomen. (Nva2)-Cs was used in three experimental protocols (1) single or three (Nva2)-Cs injections given to lung-transplanted rats, (2) daily oral (Nva2)-Cs treatment at different doses compared with similar CsA treatments in heart allografted rats, and (3) An 11-day (Nva2)-Cs treatment starting at increasing intervals after transplantation of hearts. (Nva2)-Cs was found to be immunosuppressive, and effective even when the treatment started as late as four days after transplantation. However, (Nva2)-Cs was less effective than CsA in suppressing rejection of lung and heart allografts at low doses. Because (Nva2)-Cs is possibly not nephrotoxic, it might be a useful drug if used in higher doses than CsA or in combination with other immunosuppressive agents.
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Database:
MEDLINE
Main subject:
Heart-Lung Transplantation
/
Heart Transplantation
/
Lung Transplantation
/
Cyclosporine
/
Cyclosporins
/
Graft Rejection
Type of study:
Guideline
Language:
En
Journal:
Transplantation
Year:
1987
Type:
Article