Dihydroagarofuran sesquiterpenoids esterified with organic acids from the leaves of Tripterygium wilfordii.
Fitoterapia
; 137: 104185, 2019 Sep.
Article
in En
| MEDLINE
| ID: mdl-31150768
ABSTRACT
Six new and one known dihydroagarofuran sesquiterpenoids esterified with organic acids were obtained from the leaves of Tripterygium wilfordii. Spectroscopic techniques (UV, IR, MS, NMR, ORD and CD) were used for the structure elucidation of the compounds. The structures of compounds 1 and 2 were confirmed by X-ray single crystallographic analyses. The inhibitory effects on NO production in LPS-induced macrophages of 1-7 were conducted. At 10⯵mol/L, compounds 1, 2 and 7 showed moderate inhibitory effects on NO production in LPS-induced macrophages with inhibitory rate at 31.2⯱â¯3.6, 40.9⯱â¯4.3, and 66.79⯱â¯3.1%, respectively.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Sesquiterpenes
/
Tripterygium
/
Macrophages
Language:
En
Journal:
Fitoterapia
Year:
2019
Type:
Article