Health implication of vitamin D on the cardiovascular and the renal system.
Arch Physiol Biochem
; 127(3): 195-209, 2021 Jun.
Article
in En
| MEDLINE
| ID: mdl-31291127
ABSTRACT
Vitamin D regulates the calcium and phosphorus balance in the body. The activated form of vitamin D (1 α,25-dihydroxyvitamin D) binds to vitamin D receptor which regulates genes that control cell proliferation, differentiation and apoptosis. In the cardiovascular system, the vitamin D receptor is present in cardiomyocytes and the arterial wall. A clear correlation between vitamin D level and cardiovascular diseases is established. Vitamin D deficiency affects the renin-angiotensin system leading to ventricular hypertrophy and eventually to stroke. While clinical trials highlighted the positive effects of vitamin D supplements on cardiovascular disease these still need to be confirmed. This review outlines the association between vitamin D and cardiovascular and renal disease summarising the experimental data of selective cardiovascular disorders.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Vitamin D
/
Cardiovascular System
/
Health
/
Kidney
Language:
En
Journal:
Arch Physiol Biochem
Year:
2021
Type:
Article
Affiliation country:
Qatar