Impact of Transferrin Saturation on All-Cause Mortality in Patients on Maintenance Hemodialysis.
Blood Purif
; 48(2): 158-166, 2019.
Article
in En
| MEDLINE
| ID: mdl-31311016
ABSTRACT
BACKGROUND:
Transferrin saturation (TSAT) is an index that represents the iron-binding capacity of transferrin, which is the main transport protein for iron, and is widely used to evaluate iron status.OBJECTIVE:
To evaluate the prognostic importance of TSAT in Japanese patients on maintenance hemodialysis (MHD).METHODS:
A total of 398 patients on MHD were recruited and divided into 3 groups on the basis of their baseline TSAT levels (<20, 20-40, and >40%).RESULTS:
There was no difference in the proportion of patients on erythropoiesis-stimulating agents or iron supplements between the 3 groups. During a mean follow-up period of 52.2 ± 1 6.3 months, 130 patients died of cardiovascular causes (n = 63, 15.8%) or infection (n = 47, 11.8%). Compared with the reference group (TSAT 20-40%), patients with a TSAT <20% had a significantly higher all-cause mortality rate (6.44 vs. 9.55 events per 100 patient-years, p = 0.0452). Kaplan-Meier analysis showed that all-cause mortality rate was significantly higher in patients with TSAT <20% than in the other 2 groups (p = 0.0353).CONCLUSIONS:
Low TSAT was a significant independent risk factor for all-cause mortality in a cohort of Japanese patients on MHD. The findings of this study suggest that the adverse clinical outcomes in patients with low TSAT can be partly attributed to infection-related iron deficiency.Key words
Full text:
1
Database:
MEDLINE
Main subject:
Transferrin
/
Renal Dialysis
/
Kidney Failure, Chronic
Type of study:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Language:
En
Journal:
Blood Purif
Year:
2019
Type:
Article
Affiliation country:
Japan