Four New Pterosins from Pteris cretica and Their Cytotoxic Activities.
Molecules
; 24(15)2019 Jul 30.
Article
in En
| MEDLINE
| ID: mdl-31366093
ABSTRACT
Phytochemical investigation of the aerial parts of Pteris cretica led to the isolation and elucidation of nine pterosins, including four new pterosins, creticolacton A (1), 13-hydroxy-2(R),3(R)-pterosin L (2), creticoside A (3), and spelosin 3-O-ß-d-glucopyranoside (4), together with five known pterosins 5-9. Their structures were identified mainly on the basis of 1D and 2D NMR spectral data, ESI-MS and literature comparisons. Compounds 1 and 3 were new type of petrosins with a six membered ring between C-14 and C-15. The new compounds were tested in vitro for their cytotoxic activities against four human tumor cell lines (SH-SY5Y, SGC-7901, HCT-116, Lovo). Results showed that compounds 1 and 2 exhibited cytotoxic activity against HCT-116 cells with IC50 value of 22.4 µM and 15.8 µM, respectively.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Sesquiterpenes
/
Cytotoxins
/
Pteris
/
Indans
/
Antineoplastic Agents, Phytogenic
Language:
En
Journal:
Molecules
Year:
2019
Type:
Article
Affiliation country:
China