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Protective effect of Corchorus capsularis L. leaves on ethanol-induced acute gastric mucosal lesion in rats.
Lee, Chiu-Fang; Fan, Ching-Wen; Chiang, Ni-Na; Chang, Hsiou-Chuan; Chen, Chun; Huang, Yu-Syuan; Wang, Hui-Yun; Lin, Wen-Chuan; Chen, Fu-An.
Affiliation
  • Lee CF; Kaohsiung Veterans General Hospital Pingtung Branch, Pingtung 912, Taiwan.
  • Fan CW; Department of Pharmacy and Master Program, Tajen University, Pingtung 907, Taiwan.
  • Chiang NN; Kaohsiung Veterans General Hospital Pingtung Branch, Pingtung 912, Taiwan.
  • Chang HC; Department of Pharmacy and Master Program, Tajen University, Pingtung 907, Taiwan.
  • Chen C; Department of Pharmacy and Master Program, Tajen University, Pingtung 907, Taiwan.
  • Huang YS; Department of Pharmacy and Master Program, Tajen University, Pingtung 907, Taiwan.
  • Wang HY; Department of Pharmacy and Master Program, Tajen University, Pingtung 907, Taiwan.
  • Lin WC; Taiwan Association of Chinese Medicine, Chiayi 600, Taiwan.
  • Chen FA; Department of Pharmacy and Master Program, Tajen University, Pingtung 907, Taiwan.
J Vet Med Sci ; 81(11): 1636-1642, 2019 Nov 29.
Article in En | MEDLINE | ID: mdl-31527352
ABSTRACT
In Taiwan, Corchorus capsularis L. has long been cultivated and the leaves are consumed as edible vegetable. This study is to investigate the protection effect of extract of C. capsularis leaves (ECC) on ethanol-induced acute gastric mucosal lesion (AGML) in rats. The results of phytochemical determination in ECC for total polyphenol, flavonoid and polysaccharide were 59.88 ± 0.61 mg/g, 86.39 ± 18.0 mg/g and 320.89 ± 6.99 mg/g, respectively. ECC showed significant activity of 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging with IC50 of 0.25 mg/ml. In vivo studies, Sprague-Dawley (SD) rats were randomly divided into five groups sham, vehicle (control) and low-, medium-, and high-dose ECC (LECC, MECC, HECC; 200, 400, and 1,000 mg/kg/day, respectively). ECC was able to decrease significantly the ulcer index (UI) caused by 80% ethanol in a dose dependent manner. There was no significant effect on growth trend and food intake rate after the administration of ECC in the experimental period. The serum lipid parameters in ECC groups revealed significant increase in glutathione peroxidase (GPx), superoxide dilmutase (SOD) and catalase (CAT), and a decrease in malondialdehyde (MDA). Significant amelioration on pathological lesion score was found in ECC groups compared with the control group (P<0.05). The overall results indicate that ECC has protective effects on ethanol-induced AGML in rats, which could be associated with its antioxidant activity.
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Full text: 1 Database: MEDLINE Main subject: Stomach Ulcer / Plant Extracts / Corchorus Language: En Journal: J Vet Med Sci Year: 2019 Type: Article Affiliation country: Taiwan

Full text: 1 Database: MEDLINE Main subject: Stomach Ulcer / Plant Extracts / Corchorus Language: En Journal: J Vet Med Sci Year: 2019 Type: Article Affiliation country: Taiwan