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Zinc abrogates anticancer drug tamoxifen-induced hepatotoxicity by suppressing redox imbalance, NO/iNOS/NF-ĸB signaling, and caspase-3-dependent apoptosis in female rats.
Famurewa, Ademola C; Ekeleme-Egedigwe, Chima A; David, Ebuka E; Eleazu, Chinedum O; Folawiyo, Abiola M; Obasi, Nwogo A.
Affiliation
  • Famurewa AC; Department of Medical Biochemistry, Faculty of Basic Medical Sciences, College of Medicine, Alex Ekwueme Federal University, Ikwo, Nigeria.
  • Ekeleme-Egedigwe CA; Biochemistry Division, Amala Cancer Research Centre, Amala Institute of Medical Sciences, Thrissur, India.
  • David EE; Department of Chemistry/Biochemistry and Molecular Biology, Faculty of Science, Alex-Ekwueme Federal University, Ikwo, Nigeria.
  • Eleazu CO; Department of Chemistry/Biochemistry and Molecular Biology, Faculty of Science, Alex-Ekwueme Federal University, Ikwo, Nigeria.
  • Folawiyo AM; Department of Chemistry/Biochemistry and Molecular Biology, Faculty of Science, Alex-Ekwueme Federal University, Ikwo, Nigeria.
  • Obasi NA; Department of Physiology, School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia.
Toxicol Mech Methods ; 30(2): 115-123, 2020 Feb.
Article in En | MEDLINE | ID: mdl-31532279
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Full text: 1 Database: MEDLINE Main subject: Tamoxifen / Chlorides / Apoptosis / Zinc Compounds / Oxidative Stress / Protective Agents / Chemical and Drug Induced Liver Injury Language: En Journal: Toxicol Mech Methods Year: 2020 Type: Article Affiliation country: Nigeria
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Full text: 1 Database: MEDLINE Main subject: Tamoxifen / Chlorides / Apoptosis / Zinc Compounds / Oxidative Stress / Protective Agents / Chemical and Drug Induced Liver Injury Language: En Journal: Toxicol Mech Methods Year: 2020 Type: Article Affiliation country: Nigeria