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Fragment-based discovery of the first nonpeptidyl inhibitor of an S46 family peptidase.
Sakamoto, Yasumitsu; Suzuki, Yoshiyuki; Nakamura, Akihiro; Watanabe, Yurie; Sekiya, Mizuki; Roppongi, Saori; Kushibiki, Chisato; Iizuka, Ippei; Tani, Osamu; Sakashita, Hitoshi; Inaka, Koji; Tanaka, Hiroaki; Yamada, Mitsugu; Ohta, Kazunori; Honma, Nobuyuki; Shida, Yosuke; Ogasawara, Wataru; Nakanishi-Matsui, Mayumi; Nonaka, Takamasa; Gouda, Hiroaki; Tanaka, Nobutada.
Affiliation
  • Sakamoto Y; School of Pharmacy, Iwate Medical University, 1-1-1 Idaidori, Yahaba, Iwate, 028-3694, Japan.
  • Suzuki Y; Department of Bioengineering, Nagaoka University of Technology, 1603-1 Kamitomioka, Nagaoka, Niigata, 940-2188, Japan.
  • Nakamura A; National Institute of Technology, Nagaoka College, 888 Nishikatakai, Nagaoka, Niigata, 940-8532, Japan.
  • Watanabe Y; Department of Bioengineering, Nagaoka University of Technology, 1603-1 Kamitomioka, Nagaoka, Niigata, 940-2188, Japan.
  • Sekiya M; School of Pharmacy, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8555, Japan.
  • Roppongi S; School of Pharmacy, Iwate Medical University, 1-1-1 Idaidori, Yahaba, Iwate, 028-3694, Japan.
  • Kushibiki C; School of Pharmacy, Iwate Medical University, 1-1-1 Idaidori, Yahaba, Iwate, 028-3694, Japan.
  • Iizuka I; School of Pharmacy, Iwate Medical University, 1-1-1 Idaidori, Yahaba, Iwate, 028-3694, Japan.
  • Tani O; School of Pharmacy, Iwate Medical University, 1-1-1 Idaidori, Yahaba, Iwate, 028-3694, Japan.
  • Sakashita H; Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), 1-1-1 Higashi, Tsukuba, Ibaraki, 305-8566, Japan.
  • Inaka K; Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), 1-1-1 Higashi, Tsukuba, Ibaraki, 305-8566, Japan.
  • Tanaka H; Maruwa Foods and Biosciences Inc., 170-1 Tsutsui-cho, Yamatokoriyama, Nara, 639-1123, Japan.
  • Yamada M; Confocal Science Inc., 2-12-2 Iwamoto-cho, Chiyoda-ku, Tokyo, 101-0032, Japan.
  • Ohta K; Japan Aerospace Exploration Agency (JAXA), 2-1-1 Sengen, Tsukuba, Ibaraki, 305-8505, Japan.
  • Honma N; Japan Aerospace Exploration Agency (JAXA), 2-1-1 Sengen, Tsukuba, Ibaraki, 305-8505, Japan.
  • Shida Y; Department of Bioengineering, Nagaoka University of Technology, 1603-1 Kamitomioka, Nagaoka, Niigata, 940-2188, Japan.
  • Ogasawara W; Department of Bioengineering, Nagaoka University of Technology, 1603-1 Kamitomioka, Nagaoka, Niigata, 940-2188, Japan.
  • Nakanishi-Matsui M; Department of Bioengineering, Nagaoka University of Technology, 1603-1 Kamitomioka, Nagaoka, Niigata, 940-2188, Japan.
  • Nonaka T; School of Pharmacy, Iwate Medical University, 1-1-1 Idaidori, Yahaba, Iwate, 028-3694, Japan.
  • Gouda H; School of Pharmacy, Iwate Medical University, 1-1-1 Idaidori, Yahaba, Iwate, 028-3694, Japan.
  • Tanaka N; School of Pharmacy, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8555, Japan.
Sci Rep ; 9(1): 13587, 2019 09 19.
Article in En | MEDLINE | ID: mdl-31537874
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Full text: 1 Database: MEDLINE Main subject: Benzoates / Porphyromonas gingivalis / Citric Acid / Dipeptidyl-Peptidases and Tripeptidyl-Peptidases Language: En Journal: Sci Rep Year: 2019 Type: Article Affiliation country: Japan
Fulltext
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Full text: 1 Database: MEDLINE Main subject: Benzoates / Porphyromonas gingivalis / Citric Acid / Dipeptidyl-Peptidases and Tripeptidyl-Peptidases Language: En Journal: Sci Rep Year: 2019 Type: Article Affiliation country: Japan