Astragalus root extract inhibits retinal cell apoptosis and repairs damaged retinal neovascularization in retinopathy of prematurity.

Liu, Xiaojun; Wang, Bin; Sun, Yongfa; Jia, Yutao; Xu, Zhaoying

Liu, Xiaojun; Wang, Bin; Sun, Yongfa; Jia, Yutao; Xu, Zhaoying.

Affiliation

Liu X; Department of Pediatrics, Luoyang Central Hospital Affiliated to Zhengzhou University , Luoyang , PR. China.
Wang B; Department of Pediatrics, Luoyang Women's and Children's Health Care Center , Luoyang , PR. China.
Sun Y; Department of Pediatrics, Luoyang Central Hospital Affiliated to Zhengzhou University , Luoyang , PR. China.
Jia Y; Department of Pediatrics, Luoyang Central Hospital Affiliated to Zhengzhou University , Luoyang , PR. China.
Xu Z; Department of Pediatrics, Luoyang Central Hospital Affiliated to Zhengzhou University , Luoyang , PR. China.

Cell Cycle ; 18(22): 3147-3159, 2019 11.

Article in En | MEDLINE | ID: mdl-31564208

Subject(s)

Apoptosis/drug effects; Astragalus Plant/chemistry; Neovascularization, Pathologic/drug therapy; Plant Extracts/therapeutic use; Retina/drug effects; Retinal Vessels; Retinopathy of Prematurity/drug therapy; Retinopathy of Prematurity/metabolism; Animals; Disease Models, Animal; Endothelial Cells/metabolism; Endothelial Cells/ultrastructure; Eye Proteins/genetics; Eye Proteins/metabolism; Hypoxia-Inducible Factor 1, alpha Subunit/genetics; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism; Insulin-Like Growth Factor I/genetics; Insulin-Like Growth Factor I/metabolism; Mice; Mice, Inbred C57BL; Microscopy, Electron; Neovascularization, Pathologic/metabolism; Nerve Growth Factors/genetics; Nerve Growth Factors/metabolism; Nitric Oxide Synthase Type I/genetics; Nitric Oxide Synthase Type I/metabolism; Nitric Oxide Synthase Type II/genetics; Nitric Oxide Synthase Type II/metabolism; Nitric Oxide Synthase Type III/genetics; Nitric Oxide Synthase Type III/metabolism; Oxygen/toxicity; Plant Extracts/pharmacology; Proto-Oncogene Proteins c-bcl-2/metabolism; Reactive Oxygen Species/metabolism; Retina/cytology; Retina/pathology; Retina/ultrastructure; Retinopathy of Prematurity/chemically induced; Retinopathy of Prematurity/genetics; Serpins/genetics; Serpins/metabolism; Vascular Endothelial Growth Factor A/genetics; Vascular Endothelial Growth Factor A/metabolism; bcl-2-Associated X Protein/metabolism

Key words

Astragalus root extract; oxygen induced retinopathy; retinopathy of prematurity

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Full text: 1 Database: MEDLINE Therapeutic Methods and Therapies TCIM: Terapias_biologicas / Plantas_medicinales Main subject: Retina / Retinal Vessels / Retinopathy of Prematurity / Plant Extracts / Apoptosis / Astragalus Plant / Neovascularization, Pathologic Type of study: Prognostic_studies Language: En Journal: Cell Cycle Year: 2019 Type: Article

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