Your browser doesn't support javascript.
loading
Quantitative systems toxicology (QST) reproduces species differences in PF-04895162 liver safety due to combined mitochondrial and bile acid toxicity.
Generaux, Grant; Lakhani, Vinal V; Yang, Yuching; Nadanaciva, Sashi; Qiu, Luping; Riccardi, Keith; Di, Li; Howell, Brett A; Siler, Scott Q; Watkins, Paul B; Barton, Hugh A; Aleo, Michael D; Shoda, Lisl K M.
Affiliation
  • Generaux G; DILIsym Services Inc. Research Triangle Park North Carolina.
  • Lakhani VV; DILIsym Services Inc. Research Triangle Park North Carolina.
  • Yang Y; DILIsym Services Inc. Research Triangle Park North Carolina.
  • Nadanaciva S; Present address: Division of Pharmacometrics Office of Clinical Pharmacology Office of Translational Sciences Center for Drug Evaluation and Research Food and Drug Administration Food and Drug Administration Silver Spring Maryland.
  • Qiu L; Compound Safety Prediction Worldwide Medicinal Chemistry Pfizer Inc. Groton Connecticut.
  • Riccardi K; Investigative Toxicology Drug Safety Research and Development Pfizer Inc. Groton Connecticut.
  • Di L; Pharmacokinetics, Dynamics and Metabolism Medicinal Sciences Pfizer Inc. Groton Connecticut.
  • Howell BA; Pharmacokinetics, Dynamics and Metabolism Medicinal Sciences Pfizer Inc. Groton Connecticut.
  • Siler SQ; DILIsym Services Inc. Research Triangle Park North Carolina.
  • Watkins PB; DILIsym Services Inc. Research Triangle Park North Carolina.
  • Barton HA; UNC Eshelman School of Pharmacy University of North Carolina at Chapel Hill Chapel Hill North Carolina.
  • Aleo MD; UNC Institute for Drug Safety Sciences University of North Carolina at Chapel Hill Chapel Hill North Carolina.
  • Shoda LKM; Translational Modeling and Simulation Biomedicine Design Pfizer, Inc. Groton Connecticut.
Pharmacol Res Perspect ; 7(6): e00523, 2019 12.
Article in En | MEDLINE | ID: mdl-31624633
Subject(s)
Key words
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Database: MEDLINE Main subject: Quinazolines / Chemical and Drug Induced Liver Injury / ATP Binding Cassette Transporter, Subfamily B, Member 11 / Models, Biological / Anticonvulsants Type of study: Clinical_trials / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Language: En Journal: Pharmacol Res Perspect Year: 2019 Type: Article
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Database: MEDLINE Main subject: Quinazolines / Chemical and Drug Induced Liver Injury / ATP Binding Cassette Transporter, Subfamily B, Member 11 / Models, Biological / Anticonvulsants Type of study: Clinical_trials / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Language: En Journal: Pharmacol Res Perspect Year: 2019 Type: Article