Cytotoxic and anti-inflammatory constituents from Momordica cochinchinensis seeds.
Fitoterapia
; 139: 104360, 2019 Nov.
Article
in En
| MEDLINE
| ID: mdl-31629869
ABSTRACT
Five new lignans mubiesins Aâ¯-â¯E (1-5), together with twenty-seven known compounds (6-32), were isolated from the cytotoxicity and anti-inflammation portions of Momordica cochinchinensis seeds which were widely used for various tumors and inflammations. Their structures were elucidated by extensive spectroscopic analyses (HR-MS, UV, CD, IR, 1D-NMR, and 2D-NMR). Their cytotoxic and anti-inflammatory activities were evaluated in vitro. Various lignans and saponins showed the significant activities, they could obviously inhibit the growth of tumor cells and the release of NO and TNF-α in RAW 264.7 cells induced by LPS.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Saponins
/
Seeds
/
Lignans
/
Momordica
/
Anti-Inflammatory Agents
/
Antineoplastic Agents, Phytogenic
Country/Region as subject:
Asia
Language:
En
Journal:
Fitoterapia
Year:
2019
Type:
Article
Affiliation country:
China