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High-throughput screening yields several small-molecule inhibitors of repeat-associated non-AUG translation.
Green, Katelyn M; Sheth, Udit J; Flores, Brittany N; Wright, Shannon E; Sutter, Alexandra B; Kearse, Michael G; Barmada, Sami J; Ivanova, Magdalena I; Todd, Peter K.
Affiliation
  • Green KM; Department of Neurology, University of Michigan, Ann Arbor, Michigan 48109; Cellular and Molecular Biology Program, University of Michigan, Ann Arbor, Michigan 48109.
  • Sheth UJ; Department of Neurology, University of Michigan, Ann Arbor, Michigan 48109.
  • Flores BN; Department of Neurology, University of Michigan, Ann Arbor, Michigan 48109; Cellular and Molecular Biology Program, University of Michigan, Ann Arbor, Michigan 48109.
  • Wright SE; Department of Neurology, University of Michigan, Ann Arbor, Michigan 48109.
  • Sutter AB; Department of Neurology, University of Michigan, Ann Arbor, Michigan 48109.
  • Kearse MG; Department of Neurology, University of Michigan, Ann Arbor, Michigan 48109; Department of Biological Chemistry and Pharmacology, Center for RNA Biology, Ohio State University, Columbus, Ohio 43210.
  • Barmada SJ; Department of Neurology, University of Michigan, Ann Arbor, Michigan 48109; Cellular and Molecular Biology Program, University of Michigan, Ann Arbor, Michigan 48109.
  • Ivanova MI; Department of Neurology, University of Michigan, Ann Arbor, Michigan 48109; Biophysics Program, University of Michigan, Ann Arbor, Michigan 48109.
  • Todd PK; Department of Neurology, University of Michigan, Ann Arbor, Michigan 48109; Cellular and Molecular Biology Program, University of Michigan, Ann Arbor, Michigan 48109; Veterans Affairs Ann Arbor Healthcare System, Ann Arbor, Michigan 48105. Electronic address: petertod@umich.edu.
J Biol Chem ; 294(49): 18624-18638, 2019 12 06.
Article in En | MEDLINE | ID: mdl-31649034
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Full text: 1 Database: MEDLINE Main subject: Ataxia / Tremor / Trinucleotide Repeat Expansion / Fragile X Syndrome / Amyotrophic Lateral Sclerosis Type of study: Diagnostic_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Language: En Journal: J Biol Chem Year: 2019 Type: Article
Fulltext
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Full text: 1 Database: MEDLINE Main subject: Ataxia / Tremor / Trinucleotide Repeat Expansion / Fragile X Syndrome / Amyotrophic Lateral Sclerosis Type of study: Diagnostic_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Language: En Journal: J Biol Chem Year: 2019 Type: Article