Safety evaluation of calcium L-methylfolate.

Niederberger, K E; Dahms, I; Broschard, T H; Boehni, R; Moser, R

Niederberger, K E; Dahms, I; Broschard, T H; Boehni, R; Moser, R.

Affiliation

Niederberger KE; Leveret GmbH, Aberenrain 30, 6340, Baar, Switzerland.
Dahms I; DSM Nutritional Products, Wurmisweg 576, 4303, Kaiseraugst, Switzerland.
Broschard TH; Merck KGaA, Frankfurter Strasse 250, 64293, Darmstadt, Germany.
Boehni R; Merck & Cie, Im Laternenacker 5, 8200, Schaffhausen, Switzerland.
Moser R; Merck & Cie, Im Laternenacker 5, 8200, Schaffhausen, Switzerland.

Toxicol Rep ; 6: 1018-1030, 2019.

Article in En | MEDLINE | ID: mdl-31673504

Key words

5-MTHF, 5-methyltetrahydrofolate; ANOVA, analysis of variance; BaP, benzo[a]pyrene; Calcium L-methylfolate; Developmental toxicity; EFSA, European Food Safety Authority; GD, gestation day; GLP, Good Laboratory Practice; GRAS, generally recognized as safe; Genotoxicity; HPLC, High Performance Liquid Chromatography; JECFA, Joint FAO/WHO Expert Committee on Food Additives; L-5-MTHF-Ca; L-5-MTHF-Ca, calcium L-methylfolate; MTT, 3-[45-dimethylthiazole-2-yl]-2,5-diphenylbromide; NNG, net grains/nucleus; NOAEL, No Observed Adverse Effect Level; OECD, Organisation for Economic Co-operation and Development; TFT, 5-trifluorothymidine; Toxicity; USP, United States Pharmacopeia; WE-I, Williams E medium-Incomplete; bw, body weight

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Full text: 1 Database: MEDLINE Type of study: Prognostic_studies Language: En Journal: Toxicol Rep Year: 2019 Type: Article Affiliation country: Switzerland

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Full text: 1 Database: MEDLINE Type of study: Prognostic_studies Language: En Journal: Toxicol Rep Year: 2019 Type: Article Affiliation country: Switzerland