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Superinfection of hepatitis A virus in hepatocytes infected with hepatitis B virus.
Win, Nan Nwe; Kanda, Tatsuo; Ogawa, Masahiro; Nakamoto, Shingo; Haga, Yuki; Sasaki, Reina; Nakamura, Masato; Wu, Shuang; Matsumoto, Naoki; Matsuoka, Shunichi; Kato, Naoya; Shirasawa, Hiroshi; Yokosuka, Osamu; Okamoto, Hiroaki; Moriyama, Mitsuhiko.
Affiliation
  • Win NN; Department of Molecular Virology, Graduate School of Medicine, Chiba University, Inohana 1-8-1, Chuo-ku, Chiba 260-8677, Japan.
  • Kanda T; Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, 30-1 Oyaguchi-Kamicho, Itabashi-ku, Tokyo 173-8610, Japan; kanda.tatsuo@nihon-u.ac.jp (T.K.).
  • Ogawa M; Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, 30-1 Oyaguchi-Kamicho, Itabashi-ku, Tokyo 173-8610, Japan; kanda.tatsuo@nihon-u.ac.jp (T.K.).
  • Nakamoto S; Department of Molecular Virology, Graduate School of Medicine, Chiba University, Inohana 1-8-1, Chuo-ku, Chiba 260-8677, Japan.
  • Haga Y; Department of Gastroenterology, Chiba University, Inohana 1-8-1, Chuo-ku, Chiba 260-8677, Japan.
  • Sasaki R; Department of Gastroenterology, Chiba University, Inohana 1-8-1, Chuo-ku, Chiba 260-8677, Japan.
  • Nakamura M; Department of Gastroenterology, Chiba University, Inohana 1-8-1, Chuo-ku, Chiba 260-8677, Japan.
  • Wu S; Department of Gastroenterology, Chiba University, Inohana 1-8-1, Chuo-ku, Chiba 260-8677, Japan.
  • Matsumoto N; Department of Gastroenterology, Chiba University, Inohana 1-8-1, Chuo-ku, Chiba 260-8677, Japan.
  • Matsuoka S; Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, 30-1 Oyaguchi-Kamicho, Itabashi-ku, Tokyo 173-8610, Japan; kanda.tatsuo@nihon-u.ac.jp (T.K.).
  • Kato N; Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, 30-1 Oyaguchi-Kamicho, Itabashi-ku, Tokyo 173-8610, Japan; kanda.tatsuo@nihon-u.ac.jp (T.K.).
  • Shirasawa H; Department of Gastroenterology, Chiba University, Inohana 1-8-1, Chuo-ku, Chiba 260-8677, Japan.
  • Yokosuka O; Department of Molecular Virology, Graduate School of Medicine, Chiba University, Inohana 1-8-1, Chuo-ku, Chiba 260-8677, Japan.
  • Okamoto H; Department of Gastroenterology, Chiba University, Inohana 1-8-1, Chuo-ku, Chiba 260-8677, Japan.
  • Moriyama M; Division of Virology, Department of Infection and Immunity, Jichi Medical University School of Medicine, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan.
Int J Med Sci ; 16(10): 1366-1370, 2019.
Article in En | MEDLINE | ID: mdl-31692913
ABSTRACT
Hepatitis A virus (HAV) infection is a major cause of acute hepatitis including acute liver failure. Hepatitis B infection (HBV) occurs worldwide, with the highest rates in Asian and African countries, and there are several reports that HAV infection may have a more severe clinical course in patients with chronic HBV infection. We previously demonstrated that Japanese miso extracts have inhibitory effects on HAV replication. In the present study, we examined the replication of HAV and HBV in a hepatocyte superinfection model and the inhibitory effects of Japanese miso extracts on both viruses. According to the results, HAV infection inhibited HBV replication in superinfected hepatocytes, and Japanese rice-koji miso extracts had inhibitory effects on HAV replication. Our findings provide useful information for clinicians in managing HAV infection in patients with chronic HBV infection.
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Full text: 1 Database: MEDLINE Main subject: Virus Replication / Plant Extracts / Superinfection / Hepatitis B, Chronic / Hepatitis A Type of study: Prognostic_studies Language: En Journal: Int J Med Sci Year: 2019 Type: Article Affiliation country: Japan
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Full text: 1 Database: MEDLINE Main subject: Virus Replication / Plant Extracts / Superinfection / Hepatitis B, Chronic / Hepatitis A Type of study: Prognostic_studies Language: En Journal: Int J Med Sci Year: 2019 Type: Article Affiliation country: Japan