Costunolide inhibits osteosarcoma growth and metastasis via suppressing STAT3 signal pathway.

Jin, Xinmeng; Wang, Congcong; Wang, Lei

Jin, Xinmeng; Wang, Congcong; Wang, Lei.

Affiliation

Jin X; Department of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China.
Wang C; Department of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China.
Wang L; Department of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. Electronic address: thunderwang@126.com.

Biomed Pharmacother ; 121: 109659, 2020 Jan.

Article in En | MEDLINE | ID: mdl-31739161

Subject(s)

Cell Proliferation/drug effects; Osteosarcoma/drug therapy; STAT3 Transcription Factor/metabolism; Sesquiterpenes/pharmacology; Signal Transduction/drug effects; Animals; Antineoplastic Agents, Phytogenic/pharmacology; Cell Line, Tumor; Humans; Male; Mice; Mice, Nude; Osteosarcoma/metabolism

Key words

Costunolide; STAT3; growth and metastasis; osteosarcoma

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Full text: 1 Database: MEDLINE Main subject: Sesquiterpenes / Signal Transduction / Osteosarcoma / Cell Proliferation / STAT3 Transcription Factor Language: En Journal: Biomed Pharmacother Year: 2020 Type: Article Affiliation country: China

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