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Pyrazolopyrimide library screening in glioma cells discovers highly potent antiproliferative leads that target the PI3K/mTOR pathway.
Valero, Teresa; Baillache, Daniel J; Fraser, Craig; Myers, Samuel H; Unciti-Broceta, Asier.
Affiliation
  • Valero T; Cancer Research UK Edinburgh Centre, MRC Institute of Genetics & Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XR, UK.
  • Baillache DJ; Cancer Research UK Edinburgh Centre, MRC Institute of Genetics & Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XR, UK.
  • Fraser C; Cancer Research UK Edinburgh Centre, MRC Institute of Genetics & Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XR, UK.
  • Myers SH; Cancer Research UK Edinburgh Centre, MRC Institute of Genetics & Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XR, UK.
  • Unciti-Broceta A; Cancer Research UK Edinburgh Centre, MRC Institute of Genetics & Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XR, UK. Electronic address: Asier.Unciti-Broceta@igmm.ed.ac.uk.
Bioorg Med Chem ; 28(1): 115215, 2020 01 01.
Article in En | MEDLINE | ID: mdl-31787462
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Full text: 1 Database: MEDLINE Main subject: Pyrazoles / Pyrimidines / Phosphatidylinositol 3-Kinases / Protein Kinase Inhibitors / TOR Serine-Threonine Kinases Type of study: Diagnostic_studies / Screening_studies Language: En Journal: Bioorg Med Chem Year: 2020 Type: Article Affiliation country: United kingdom
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Full text: 1 Database: MEDLINE Main subject: Pyrazoles / Pyrimidines / Phosphatidylinositol 3-Kinases / Protein Kinase Inhibitors / TOR Serine-Threonine Kinases Type of study: Diagnostic_studies / Screening_studies Language: En Journal: Bioorg Med Chem Year: 2020 Type: Article Affiliation country: United kingdom