Could PCSK9 be a new therapeutic target of Eugenol? In vitro and in silico evaluation of hypothesis.

Zia, Saadiya; Batool, Sidra; Shahid, Ramla

Zia, Saadiya; Batool, Sidra; Shahid, Ramla.

Affiliation

Zia S; Department of Biosciences, COMSATS University Islamabad, 45550, Pakistan. Electronic address: saadiya_zia@yahoo.com.
Batool S; Department of Biosciences, COMSATS University Islamabad, 45550, Pakistan. Electronic address: sidra.batool@comsats.edu.pk.
Shahid R; Department of Biosciences, COMSATS University Islamabad, 45550, Pakistan. Electronic address: ramla_shahid@comsats.edu.pk.

Med Hypotheses ; 136: 109513, 2020 Mar.

Article in En | MEDLINE | ID: mdl-31812013

Subject(s)

Eugenol/pharmacology; PCSK9 Inhibitors; Precursor Cell Lymphoblastic Leukemia-Lymphoma/metabolism; Antioxidants/pharmacology; Dietary Supplements; Gene Expression Profiling; Gene Expression Regulation, Leukemic; Humans; Jurkat Cells; Ligands; Lipid Metabolism; Lipoproteins, LDL/metabolism; Molecular Docking Simulation; Neoplasm Metastasis; Proprotein Convertase 9/metabolism; Scavenger Receptors, Class E/antagonists & inhibitors; Scavenger Receptors, Class E/metabolism

Key words

Acute lymphoblastic leukemia; Antioxidant; Eugenol; Low density lipoprotein; Proprotein convertase Subtilisin/Kexin Type 9; ox-LDL receptor 1

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Full text: 1 Database: MEDLINE Therapeutic Methods and Therapies TCIM: Plantas_medicinales Main subject: Eugenol / Precursor Cell Lymphoblastic Leukemia-Lymphoma / PCSK9 Inhibitors Language: En Journal: Med Hypotheses Year: 2020 Type: Article

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