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Repurposing human kinase inhibitors to create an antibiotic active against drug-resistant Staphylococcus aureus, persisters and biofilms.
Le, Philipp; Kunold, Elena; Macsics, Robert; Rox, Katharina; Jennings, Megan C; Ugur, Ilke; Reinecke, Maria; Chaves-Moreno, Diego; Hackl, Mathias W; Fetzer, Christian; Mandl, Franziska A M; Lehmann, Johannes; Korotkov, Vadim S; Hacker, Stephan M; Kuster, Bernhard; Antes, Iris; Pieper, Dietmar H; Rohde, Manfred; Wuest, William M; Medina, Eva; Sieber, Stephan A.
Affiliation
  • Le P; Center for Integrated Protein Science at the Department of Chemistry, Technische Universität München, Garching bei München, Germany.
  • Kunold E; Chair of Organic Chemistry II, Technische Universität München, Garching bei München, Germany.
  • Macsics R; Center for Integrated Protein Science at the Department of Chemistry, Technische Universität München, Garching bei München, Germany.
  • Rox K; Chair of Organic Chemistry II, Technische Universität München, Garching bei München, Germany.
  • Jennings MC; SciLifeLab, Department of Oncology-Pathology, Karolinska Institutet, Solna, Sweden.
  • Ugur I; Center for Integrated Protein Science at the Department of Chemistry, Technische Universität München, Garching bei München, Germany.
  • Reinecke M; Chair of Organic Chemistry II, Technische Universität München, Garching bei München, Germany.
  • Chaves-Moreno D; Department of Chemical Biology, Helmholtz Centre for Infection Research, Braunschweig, Germany.
  • Hackl MW; German Centre for Infection Research, Partner Site Braunschweig-Hannover, Hannover, Germany.
  • Fetzer C; Department of Chemistry, Temple University, Philadelphia, PA, USA.
  • Mandl FAM; Center for Integrated Protein Science, TUM School of Life Sciences, Technische Universität München, Freising, Germany.
  • Lehmann J; Chair of Proteomics and Bioanalytics, Technische Universität München, Freising, Germany.
  • Korotkov VS; German Cancer Consortium, Partner Site Munich, Munich, Germany.
  • Hacker SM; German Cancer Research Center, Heidelberg, Germany.
  • Kuster B; Microbial Interactions and Processes Research Group, Helmholtz Centre for Infection Research, Braunschweig, Germany.
  • Antes I; Center for Integrated Protein Science at the Department of Chemistry, Technische Universität München, Garching bei München, Germany.
  • Pieper DH; Chair of Organic Chemistry II, Technische Universität München, Garching bei München, Germany.
  • Rohde M; Center for Integrated Protein Science at the Department of Chemistry, Technische Universität München, Garching bei München, Germany.
  • Wuest WM; Chair of Organic Chemistry II, Technische Universität München, Garching bei München, Germany.
  • Medina E; Center for Integrated Protein Science at the Department of Chemistry, Technische Universität München, Garching bei München, Germany.
  • Sieber SA; Chair of Organic Chemistry II, Technische Universität München, Garching bei München, Germany.
Nat Chem ; 12(2): 145-158, 2020 02.
Article in En | MEDLINE | ID: mdl-31844194
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Full text: 1 Database: MEDLINE Therapeutic Methods and Therapies TCIM: Terapias_biologicas / Aromoterapia / Plantas_medicinales Main subject: Protein Kinase Inhibitors / Benzodioxoles / Methicillin-Resistant Staphylococcus aureus / Drug Repositioning / Sorafenib / Anti-Bacterial Agents Language: En Journal: Nat Chem Year: 2020 Type: Article Affiliation country: Germany
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Full text: 1 Database: MEDLINE Therapeutic Methods and Therapies TCIM: Terapias_biologicas / Aromoterapia / Plantas_medicinales Main subject: Protein Kinase Inhibitors / Benzodioxoles / Methicillin-Resistant Staphylococcus aureus / Drug Repositioning / Sorafenib / Anti-Bacterial Agents Language: En Journal: Nat Chem Year: 2020 Type: Article Affiliation country: Germany