Neuroprotective racemic germacranolides from the roots of Chloranthus henryi.
Fitoterapia
; 141: 104472, 2020 Mar.
Article
in En
| MEDLINE
| ID: mdl-31917303
ABSTRACT
Three pairs of new germacranolides, (+)/(-)-chlogermacrones A-C, along with two known analogues were obtained from the roots of Chloranthus henryi. Spectroscopic techniques and single-crystal X-ray crystallographic analyses were used for the structure elucidation of the compounds. All of the isolated compounds were tested for their neuroprotective effects on H2O2 damaged PC12 cells, compounds 3 and 5 increased cell viability from 43.4 ± 1.3% to 99.6 ± 8.7 and 68.1 ± 4.8% at 10 µM, respectively.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Plant Roots
/
Neuroprotective Agents
/
Magnoliopsida
Language:
En
Journal:
Fitoterapia
Year:
2020
Type:
Article