Dietary zinc supplement militates against ketamine-induced behaviours by age-dependent modulation of oxidative stress and acetylcholinesterase activity in mice.

Onaolapo, Olakunle J; Jegede, Olayemi R; Adegoke, Omolade; Ayinde, Marufat O; Akeredolu, Oloruntola M; Onaolapo, Adejoke Y

Onaolapo, Olakunle J; Jegede, Olayemi R; Adegoke, Omolade; Ayinde, Marufat O; Akeredolu, Oloruntola M; Onaolapo, Adejoke Y.

Affiliation

Onaolapo OJ; Behavioural Neuroscience/Neuropharmacology Unit, Department of Pharmacology, Ladoke Akintola University of Technology, Osogbo, Osun, Nigeria.
Jegede OR; Department of Anatomy, Ladoke Akintola University of Technology, Ogbomosho, Oyo, Nigeria.
Adegoke O; Department of Anatomy, Ladoke Akintola University of Technology, Ogbomosho, Oyo, Nigeria.
Ayinde MO; Department of Anatomy, Ladoke Akintola University of Technology, Ogbomosho, Oyo, Nigeria.
Akeredolu OM; Department of Anatomy, Ladoke Akintola University of Technology, Ogbomosho, Oyo, Nigeria.
Onaolapo AY; Department of Anatomy, Ladoke Akintola University of Technology, Ogbomosho, Oyo, Nigeria. adegbayibiy@yahoo.com.

Pharmacol Rep ; 72(1): 55-66, 2020 Feb.

Article in En | MEDLINE | ID: mdl-32016846

Subject(s)

Dietary Supplements; Ketamine/toxicity; Oxidative Stress/drug effects; Zinc/pharmacology; Acetylcholinesterase/metabolism; Age Factors; Animals; Antioxidants/metabolism; Behavior, Animal/drug effects; Brain/drug effects; Brain/pathology; Dose-Response Relationship, Drug; Lipid Peroxidation/drug effects; Male; Maze Learning/drug effects; Mice; Zinc/administration & dosage

Key words

Antioxidant; Anxiety; Dietary supplements; Memory; Novelty-induced behaviours; Oxidative stress

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Full text: 1 Database: MEDLINE Main subject: Zinc / Oxidative Stress / Dietary Supplements / Ketamine Language: En Journal: Pharmacol Rep Year: 2020 Type: Article Affiliation country: Nigeria

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