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GLUT5-mediated fructose utilization drives lung cancer growth by stimulating fatty acid synthesis and AMPK/mTORC1 signaling.
Chen, Wen-Lian; Jin, Xing; Wang, Mingsong; Liu, Dan; Luo, Qin; Tian, Hechuan; Cai, Lili; Meng, Lifei; Bi, Rui; Wang, Lei; Xie, Xiao; Yu, Guanzhen; Li, Lihui; Dong, Changsheng; Cai, Qiliang; Jia, Wei; Wei, Wenyi; Jia, Lijun.
Affiliation
  • Chen WL; Cancer Institute, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
  • Jin X; Cancer Institute, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
  • Wang M; Department of Thoracic Cardiovascular Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
  • Liu D; Cancer Institute, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
  • Luo Q; Cancer Institute, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
  • Tian H; Cancer Institute, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
  • Cai L; Cancer Institute, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
  • Meng L; Department of Thoracic Cardiovascular Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
  • Bi R; Department of Thoracic Cardiovascular Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
  • Wang L; Department of Thoracic Cardiovascular Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
  • Xie X; Department of Thoracic Cardiovascular Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
  • Yu G; Cancer Institute, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
  • Li L; Cancer Institute, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
  • Dong C; Cancer Institute, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
  • Cai Q; Ministry of Education and Ministry of Health Key Lab of Medical Molecular Virology, School of Basic Medical Science, Fudan University, Shanghai, China.
  • Jia W; University of Hawaii Cancer Center, Honolulu, Hawaii, USA.
  • Wei W; Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
  • Jia L; Cancer Institute, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
JCI Insight ; 5(3)2020 02 13.
Article in En | MEDLINE | ID: mdl-32051337
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Full text: 1 Database: MEDLINE Main subject: Signal Transduction / Adenylate Kinase / Glucose Transporter Type 5 / Fatty Acids / Mechanistic Target of Rapamycin Complex 1 / Fructose / Lung Neoplasms Type of study: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Language: En Journal: JCI Insight Year: 2020 Type: Article Affiliation country: China
Fulltext
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Full text: 1 Database: MEDLINE Main subject: Signal Transduction / Adenylate Kinase / Glucose Transporter Type 5 / Fatty Acids / Mechanistic Target of Rapamycin Complex 1 / Fructose / Lung Neoplasms Type of study: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Language: En Journal: JCI Insight Year: 2020 Type: Article Affiliation country: China