Facile Construction of i-Motif DNA-Conjugated Gold Nanostars as Near-Infrared and pH Dual-Responsive Targeted Drug Delivery Systems for Combined Cancer Therapy.

Miao, Dandan; Yu, Yanyan; Chen, Yong; Liu, Yin; Su, Gaoxing

Miao, Dandan; Yu, Yanyan; Chen, Yong; Liu, Yin; Su, Gaoxing.

Affiliation

Miao D; School of Pharmacy, Nantong University, Nantong, Jiangsu Province 226001, China.
Yu Y; School of Pharmacy, Nantong University, Nantong, Jiangsu Province 226001, China.
Chen Y; School of Pharmacy, Nantong University, Nantong, Jiangsu Province 226001, China.
Liu Y; State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.
Su G; School of Pharmacy, Nantong University, Nantong, Jiangsu Province 226001, China.

Mol Pharm ; 17(4): 1127-1138, 2020 04 06.

Article in En | MEDLINE | ID: mdl-32092274

Subject(s)

DNA Adducts/chemistry; DNA Adducts/pharmacology; DNA/chemistry; Doxorubicin/chemistry; Doxorubicin/pharmacology; Gold/chemistry; Metal Nanoparticles/chemistry; Nanostructures/chemistry; Neoplasms/drug therapy; 3T3 Cells; Animals; Antineoplastic Agents/chemistry; Antineoplastic Agents/pharmacology; Biocompatible Materials/chemistry; Cell Line; Cell Line, Tumor; Combined Modality Therapy/methods; Drug Delivery Systems/methods; Drug Liberation; Humans; Hydrogen-Ion Concentration; MCF-7 Cells; Mice; Nanocomposites/chemistry; Phototherapy/methods

Key words

DNA nanostructures; cancer therapy; combined therapy; drug delivery; gold nanostars; stimuli-responsive

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Full text: 1 Database: MEDLINE Main subject: DNA / Doxorubicin / DNA Adducts / Nanostructures / Metal Nanoparticles / Gold / Neoplasms Language: En Journal: Mol Pharm Year: 2020 Type: Article Affiliation country: China

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