Chemokine CXCL12/physiology; Leukemia, Myeloid, Acute/metabolism; Neoplasm Proteins/physiology; Receptors, CXCR4/physiology; Signal Transduction/physiology; Animals; Antibodies, Monoclonal, Humanized/therapeutic use; Antineoplastic Agents/blood; Antineoplastic Agents/pharmacology; Antineoplastic Agents/therapeutic use; Benzylamines; Bone Marrow/pathology; Cell Adhesion/drug effects; Cell Adhesion/physiology; Cell Hypoxia; Cell Movement/physiology; Cell-Derived Microparticles; Clinical Trials as Topic; Cyclams; Drug Evaluation, Preclinical; Drug Resistance, Neoplasm; Gene Expression Regulation, Leukemic/drug effects; Gene Expression Regulation, Leukemic/physiology; Heterocyclic Compounds/pharmacology; Heterocyclic Compounds/therapeutic use; Humans; Leukemia, Myeloid, Acute/blood; Leukemia, Myeloid, Acute/drug therapy; Leukemia, Myeloid, Acute/pathology; Mice; Molecular Targeted Therapy; Neoplasm Proteins/antagonists & inhibitors; Neoplastic Stem Cells/metabolism; Neoplastic Stem Cells/pathology; Peptides/therapeutic use; Peptides, Cyclic/therapeutic use; Pyridines/therapeutic use; Receptors, CXCR4/antagonists & inhibitors; Signal Transduction/drug effects; Stem Cell Niche; Stromal Cells/metabolism; Stromal Cells/pathology; Tumor Microenvironment

CXCL12/CXCR4; acute myeloid leukaemia; cell adhesion