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Alvogyl and absorbable gelatin sponge as palatal wound dressings following epithelialized free gingival graft harvest: a randomized clinical trial.
Ehab, Karim; Abouldahab, Omneya; Hassan, Abdallah; Fawzy El-Sayed, Karim M.
Affiliation
  • Ehab K; Private dental clinic, Fayyoum, Egypt.
  • Abouldahab O; Oral Medicine and Periodontology Department, Faculty of Oral and Dental Medicine, Cairo University, Giza, Egypt.
  • Hassan A; Periodontology Department, School of Dentistry, New Giza University, Giza, Egypt.
  • Fawzy El-Sayed KM; Oral Medicine and Periodontology Department, Faculty of Oral and Dental Medicine, Cairo University, Giza, Egypt. karim.fawzy@gmail.com.
Clin Oral Investig ; 24(4): 1517-1525, 2020 Apr.
Article in En | MEDLINE | ID: mdl-32144515
ABSTRACT

OBJECTIVES:

This randomized controlled trial compares for the first time effects of Alvogyl versus absorbable gelatin sponge as palatal wound dressings on postoperative pain, amount of analgesic consumption, post-surgical bleeding, and wound re-epithelization. MATERIALS AND

METHODS:

Following sample size calculation, 36 systemically healthy patients requiring palatal mucosal graft harvesting were randomized to receive Alvogyl (intervention group, 18 patients) or absorbable gelatin sponge (control group, 18 patients) palatal dressings. Patient-reported VAS pain scores over 2 weeks were defined as primary outcome. Post-surgical bleeding, number of analgesics consumed, and complete re-epithelialization of the palatal wound for up to 5 weeks were defined as secondary outcomes.

RESULTS:

Although significantly higher VAS pain scores were reported in the control as compared with the intervention group up to 12 days post-surgically (from (median [range]) 8.5 [2-10] to 1 [0-2] and from 6 [0-10] to 0 [0-2] respectively), with higher analgesics consumption (from 2 [1-3] to 1 [0-3] and from 1 [0-3] to 0 [0-2] tablets respectively), a multivariate regression analysis considering age, gender, graft width/length, tissue thickness, analgesics intake, and dressing type demonstrated no statistically significant effect of any factor, including dressing type on VAS pain scores. At 4 weeks, 22.2% of patients in the intervention group versus 11.1% in the control group demonstrated complete re-epithelization of their palatal engraftment site, before complete re-epithelization in both groups at 5 weeks. No post-surgical bleeding was reported with both dressings.

CONCLUSIONS:

Within the study's limitations, results suggest Alvogyl as a practical palatal surgical dressing, comparable with absorbable gelatin sponge in cost, pain reduction, hemostasis, and re-epithelization properties. TRIAL REGISTRATION www.ClinicalTrials.gov Identifier NCT03402321 CLINICAL RELEVANCE Alvogyl could present a novel palatal wound dressing material, comparable with gelatin sponge.
Subject(s)
Key words

Full text: 1 Database: MEDLINE Therapeutic Methods and Therapies TCIM: Terapias_biologicas / Aromoterapia Main subject: Palate / Wound Healing / Eugenol / Oils, Volatile / Para-Aminobenzoates / Gelatin Sponge, Absorbable / Gingiva / Hydrocarbons, Iodinated Type of study: Clinical_trials / Prognostic_studies Language: En Journal: Clin Oral Investig Year: 2020 Type: Article Affiliation country: Egypt

Full text: 1 Database: MEDLINE Therapeutic Methods and Therapies TCIM: Terapias_biologicas / Aromoterapia Main subject: Palate / Wound Healing / Eugenol / Oils, Volatile / Para-Aminobenzoates / Gelatin Sponge, Absorbable / Gingiva / Hydrocarbons, Iodinated Type of study: Clinical_trials / Prognostic_studies Language: En Journal: Clin Oral Investig Year: 2020 Type: Article Affiliation country: Egypt